Needle Free IVF: Cost, Success Rate, Benefits & Risk

by | Sep 16, 2023 | IVF

Needle-Free IVF: A Revolution in Assisted Reproductive Technology

In the world of assisted reproductive technology, advancements continue to offer hope to individuals and couples struggling with infertility. One such breakthrough is Needle Free In Vitro Fertilization (IVF), a groundbreaking technique that differs significantly from traditional IVF methods. In this comprehensive guide, we will explore the concept of Needle Free IVF, its suitability for different individuals or couples, and provide a step-by-step breakdown of the Natural Cycle IVF procedure.


What is Needle-Free IVF?

Needle-Free IVF represents a remarkable departure from conventional IVF, primarily in its approach to stimulation and egg retrieval. Unlike traditional IVF, which involves multiple injections of hormones to stimulate the ovaries, Needle-Free IVF relies on the natural menstrual cycle of the patient.

The core principles of Needle-Free IVF include:

  • Minimal Medication: Unlike traditional IVF, where high doses of hormones are administered to stimulate the ovaries and produce multiple eggs, Needle-Free IVF typically involves minimal to no medication.
  • Natural Cycle: This approach leverages the woman’s natural menstrual cycle, allowing the retrieval of a single egg or sometimes a few, depending on the individual’s response.
  • Reduced Side Effects: Since minimal medication is used, Needle-Free IVF is associated with fewer side effects such as mood swings and ovarian hyperstimulation syndrome (OHSS).
  • Less Financial Burden: Traditional IVF can be costly due to the need for expensive medications. Needle-Free IVF may offer a more cost-effective alternative for some.


Who Should Try Needle-Free IVF?

Needle-Free IVF may be an appealing option for several groups of individuals or couples:

  1. Poor Responders: Those who have not responded well to traditional IVF medication protocols may find Needle-Free IVF a more suitable option.
  2. Minimizing Medication: Individuals who wish to avoid the side effects and financial burden associated with high doses of IVF medications may opt for Needle-Free IVF.
  3. Women with Certain Medical Conditions: Women with medical conditions that contraindicate hormone use, such as a history of hormone-sensitive cancer, may consider Needle-Free IVF.
  4. Preserving Fertility: Some women may choose Needle-Free IVF for fertility preservation without the need for extensive medication.
  5. Egg Donors: Needle-Free IVF may be preferable for egg donors who want to avoid the discomfort and time commitment associated with hormone injections.

Now, let’s delve into the step-by-step procedure of Natural Cycle IVF, a specific form of Needle-Free IVF.


Natural Cycle IVF Procedure Step by Step

Step 1: Initial Consultation

The journey begins with an initial consultation with a fertility specialist. During this meeting, the medical history of the individual or couple is reviewed, and an assessment is made to determine if Needle-Free IVF is a suitable option.

Step 2: Baseline Assessment

If Needle-Free IVF is deemed appropriate, the next step involves a baseline assessment. This typically includes blood tests and ultrasounds to assess the current status of the ovaries and menstrual cycle.

Step 3: Monitoring the Natural Cycle

In Natural Cycle IVF, the goal is to retrieve the one or few eggs that the body naturally produces during a menstrual cycle. Hence, there is minimal hormonal intervention. Throughout the menstrual cycle, the patient is closely monitored through ultrasounds and hormone level checks to pinpoint the optimal time for egg retrieval.

Step 4: Trigger Shot

When the dominant follicle is mature, a trigger shot (typically hCG or a GnRH agonist) may be administered to ensure the precise timing of egg release.

Step 5: Egg Retrieval

Approximately 36 hours after the trigger shot, the egg retrieval procedure takes place. This is a minimally invasive procedure where a thin needle is guided through the vaginal wall into the ovaries to retrieve the mature eggs. Unlike traditional IVF, which retrieves multiple eggs, Needle-Free IVF typically focuses on obtaining just one or a few eggs.

Step 6: Fertilization

The retrieved eggs are then fertilized with sperm, either through standard insemination or intracytoplasmic sperm injection (ICSI).

Step 7: Embryo Cultivation

After fertilization, the embryos are cultured in a laboratory environment for several days, typically 3 to 5 days, to allow for their development and assessment of their quality.

Step 8: Embryo Transfer

The final step involves the transfer of one or more embryos into the woman’s uterus. This is a relatively simple and painless procedure and can be performed without the need for anesthesia.

Step 9: Pregnancy Test

After a specified period of time, usually around two weeks after the embryo transfer, a pregnancy test is conducted to determine if the procedure was successful.


Cost of Needle-Free IVF Treatment In India

The cost of Needle-Free IVF treatment in India can vary significantly based on several factors, including the city or region, the specific fertility clinic, and the individual’s unique medical circumstances. Generally, Needle-Free IVF is perceived as a more cost-effective alternative to traditional IVF due to the reduced use of medication and hormonal injections.

Here’s a breakdown of potential cost components:

  1. Consultation and Assessment: The initial consultation and baseline assessment may cost between ₹2,000 to ₹5,000 INR ($27 to $68 USD), depending on the clinic.
  2. Monitoring and Medication: Since Needle-Free IVF relies on the natural menstrual cycle, medication costs are relatively lower compared to traditional IVF, ranging from ₹10,000 to ₹20,000 INR ($136 to $272 USD).
  3. Egg Retrieval: The egg retrieval procedure typically costs between ₹15,000 to ₹30,000 INR ($204 to $408 USD).
  4. Fertilization and Embryo Culture: Costs for fertilization and embryo culture are generally included in the overall package and may range from ₹50,000 to ₹1,00,000 INR ($680 to $1,360 USD).
  5. Embryo Transfer: The embryo transfer procedure can cost around ₹10,000 to ₹20,000 INR ($136 to $272 USD).
  6. Medications and Follow-Up: Post-procedure medications and follow-up appointments may add another ₹10,000 to ₹20,000 INR ($136 to $272 USD) to the total cost.

It’s important to note that these are approximate figures, and the actual cost can vary based on the specific clinic’s pricing structure and any additional services or procedures required. Additionally, individual medical conditions and requirements may influence the overall cost.


Benefits of Needle-Free IVF Treatment

  1. Reduced Medication and Side Effects: One of the primary benefits of Needle-Free IVF is the minimal use of medication. This approach minimizes the risk of side effects associated with high doses of hormonal injections, such as mood swings and ovarian hyperstimulation syndrome (OHSS).
  2. Suitable for Poor Responders: Needle-Free IVF is often considered a viable option for individuals who have not responded well to traditional IVF medication protocols. It allows them to undergo fertility treatment with a gentler approach.
  3. Lower Financial Burden: Due to the reduced need for expensive medications, Needle-Free IVF can be more cost-effective for many patients. This makes it a more accessible option for couples or individuals seeking fertility treatment.
  4. Preserving Fertility without Discomfort: Some women may choose Needle-Free IVF for fertility preservation without the discomfort and time commitment associated with hormone injections.
  5. Avoiding Hormone-Sensitive Conditions: For individuals with medical conditions that contraindicate hormone use, such as a history of hormone-sensitive cancer, Needle-Free IVF provides a safer alternative.
  6. Convenience for Egg Donors: Egg donors may also prefer Needle-Free IVF as it reduces the discomfort and time commitment associated with hormone injections.


Success Rate of Needle-Free IVF Treatment In India

The success rate of Needle-Free IVF treatment in India, as in other countries, can vary based on various factors, including the patient’s age, overall health, the specific clinic’s expertise, and the underlying cause of infertility. However, success rates with Needle-Free IVF are generally reported to be comparable to those of traditional IVF in suitable candidates.

Success rates for Needle-Free IVF are often expressed in terms of live births per cycle. In India, these rates can range from 10% to 30% per cycle, depending on the clinic and patient profile. It’s essential to consult with a fertility specialist who can provide a personalized assessment of your chances of success with Needle-Free IVF.

Factors that may impact the success rate of Needle-Free IVF include:

  • Age: The age of the woman undergoing treatment is a significant factor. Younger women typically have higher success rates.
  • Underlying Causes of Infertility: The cause of infertility, such as tubal blockage or male factor infertility, can affect the success rate.
  • Clinic Expertise: The experience and expertise of the fertility clinic and medical team can influence outcomes.
  • Number of Treatment Cycles: The success rate may improve with multiple treatment cycles.
  • Patient’s Health and Lifestyle: General health, lifestyle factors, and adherence to medical advice also play a role.


Risk of Needle-Free IVF Treatment

While Needle-Free IVF offers numerous advantages, it is essential to acknowledge potential risks and limitations:

  1. Lower Egg Yield: One of the primary risks of Needle-Free IVF is the lower egg yield. Since this method relies on the natural menstrual cycle, it typically results in the retrieval of only one or a few eggs, compared to the multiple eggs obtained through traditional IVF with high-dose hormonal stimulation. This reduced egg yield may limit the number of embryos available for transfer or freezing.
  2. Lower Success Rate for Some: Due to the limited number of eggs retrieved in Needle-Free IVF, it may be less suitable for individuals with severe infertility issues or older women with diminished ovarian reserve. These individuals may have lower chances of success with this method compared to conventional IVF.
  3. Multiple Cycles May Be Required: Because of the limited number of eggs retrieved in each cycle, some patients may need to undergo multiple Needle-Free IVF cycles to achieve a successful pregnancy. This can increase the overall time and cost of treatment.
  4. No Control Over Egg Quantity: Natural Cycle IVF, including Needle-Free IVF, doesn’t offer the same level of control over the number of eggs retrieved as traditional IVF. In traditional IVF, more eggs can be obtained and selected, potentially increasing the chances of finding high-quality embryos.
  5. Timing Challenges: The timing of the egg retrieval in Needle-Free IVF can be challenging. It relies on the patient’s natural cycle, which may not always align with the clinic’s schedule. This can make planning and coordination more complex.
  6. Not Suitable for All Conditions: Needle-Free IVF may not be suitable for individuals with specific medical conditions that require precise hormonal control. In such cases, traditional IVF with injections and medication may be the preferred option.


Natural Cycle IVF vs. Needle-Free IVF

Natural Cycle IVF:

Natural Cycle IVF is a broader category that encompasses Needle-Free IVF. It involves minimal to no medication and hormonal stimulation. Here’s how it differs from Needle-Free IVF:

  • Stimulation Medication: In some Natural Cycle IVF variations, minimal medication may be used to prevent premature ovulation or enhance egg quality. In Needle-Free IVF, the goal is to avoid medication entirely.
  • Egg Retrieval: Both Natural Cycle IVF and Needle-Free IVF aim to retrieve eggs during a woman’s natural menstrual cycle. However, Natural Cycle IVF may involve a bit more medication to control certain aspects of the cycle.
  • Egg Yield: Natural Cycle IVF can result in the retrieval of one or a few eggs, similar to Needle-Free IVF. However, some variations of Natural Cycle IVF may attempt to retrieve more eggs by using minimal medication.
  • Suitability: Natural Cycle IVF is generally suitable for individuals who prefer a gentler approach to IVF but are willing to accept some minimal medication. It may also be used for fertility preservation.

Needle-Free IVF:

Needle-Free IVF is a specific subset of Natural Cycle IVF. Here are its unique characteristics:

  • Minimal Medication: Needle-Free IVF is characterized by a strong emphasis on avoiding medication as much as possible. It relies almost entirely on the natural menstrual cycle.
  • Low Egg Yield: Needle-Free IVF typically results in a low egg yield, aiming to retrieve one or a few eggs.
  • Suitability: It may be preferred by individuals who want to avoid injections and reduce the risk of side effects associated with hormone use.


How Is IVF Done Without Injections?

Performing IVF without injections, as in the case of Needle-Free IVF, involves the following steps:

  1. Baseline Assessment: The process begins with a thorough assessment of the woman’s natural menstrual cycle through blood tests and ultrasounds.
  2. Natural Cycle Monitoring: The woman’s natural cycle is monitored closely through ultrasounds and hormone level checks to pinpoint the optimal time for egg retrieval.
  3. Trigger Shot: When the dominant follicle is mature, a trigger shot, typically hCG or a GnRH agonist, may be administered to ensure precise timing for egg release.
  4. Egg Retrieval: Approximately 36 hours after the trigger shot, the egg retrieval procedure takes place. A thin needle is guided through the vaginal wall into the ovaries to retrieve the mature eggs.
  5. Fertilization and Embryo Culture: The retrieved eggs are fertilized with sperm, either through standard insemination or intracytoplasmic sperm injection (ICSI). The resulting embryos are cultured for several days.
  6. Embryo Transfer: One or more embryos are transferred into the woman’s uterus through a simple and relatively painless procedure.
  7. Pregnancy Test: A pregnancy test is conducted approximately two weeks after the embryo transfer to determine if the procedure was successful.


In summary, Needle-Free IVF, particularly Natural Cycle IVF, offers a unique and innovative approach to assisted reproductive technology. It minimizes the use of medication, reduces side effects, and provides an option for individuals or couples who may not have found success with traditional IVF methods. Ultimately, the decision to pursue Needle-Free IVF should be made in consultation with a qualified fertility specialist, who can provide personalized guidance based on the individual’s medical history and fertility goals.



Q: Is natural cycle IVF better?

A: Whether natural cycle IVF is better depends on individual circumstances. It’s a suitable choice for some as it involves minimal medication and a more natural approach, but may result in fewer eggs retrieved compared to traditional IVF.

Q: How painful is IVF needles?

A: The pain associated with IVF needles can vary from person to person. While some find the injections uncomfortable, the needles used are typically thin, and any pain is often manageable.

Q: Is natural IVF painful?

A: Natural IVF is generally less painful than traditional IVF because it involves fewer injections and medications. However, discomfort may still occur during procedures like egg retrieval.

Q: Is IVF painful or painless?

A: IVF procedures can be uncomfortable for some individuals but are not usually described as extremely painful. Pain can be managed with proper care and medications.

Q: What are the 3 types of IVF?

A: The three main types of IVF are traditional IVF, Mini IVF (minimal stimulation IVF), and Natural Cycle IVF. Each varies in terms of medication use and approaches to egg retrieval.

Q: What is better than IVF?

A: Alternatives to IVF include treatments like intrauterine insemination (IUI) and fertility medications. The choice depends on the specific fertility issues and patient preferences.

Q: Is IVF safer than natural?

A: IVF is generally safe when performed by experienced professionals. It can be a viable option for couples facing infertility, but it’s not inherently safer or riskier than natural conception.

Q: Is IVF normal for babies?

A: Babies born through IVF are as “normal” as those conceived naturally. IVF has been widely used for decades, and IVF-conceived children generally have similar health and development outcomes.

Q: What is most painful in IVF?

A: The most painful aspect of IVF for some individuals may be the egg retrieval procedure, which can cause discomfort or cramping. However, pain is manageable with anesthesia.

Q: Is IVF hard on a woman’s body?

A: IVF can be physically and emotionally challenging for some women due to the procedures, medications, and emotional stress. However, it does not necessarily have long-term adverse effects on a woman’s health when administered and monitored correctly.

Book Your Appointment

    Dr Mona Dahiya

    Dr Mona Dahiya

    IVF Specialist & Consultant

    Dr Mona Dahiya has performed over 5,000+ IVF cycles and is considered a global expert in IVF, ICSI, IUI and male fertility treatment. She is an eminent writer on Infertility Treatment and has over 100 Publications in both International and National Journals. Dr Mona Dahiya has immensely contributed to the field of infertility through her Research and articles.

    Recent Posts

    Best Fertility Specialist in India

    Best Fertility Specialist in India  WITH 85% SUCCESS RATE Dr. Mona Dahiya is considered one of the best fertility specialists in India for several reasons. These include her extensive experience of 25 Years, high success rates of 85% and a comprehensive approach to...

    Choosing The Right Clinic For High Ivf Success Rates In India

    CHOOSING THE RIGHT CLINIC FOR HIGH IVF SUCCESS RATES IN INDIA Choosing the right IVF clinic in India involves considering several key factors to ensure you have a high chance of success and a supportive treatment experience: Clinic’s Reputation: Opt for clinics with a...

    Best Infertility Doctors in India

    BEST INFERTILITY SPECIALIST IN INDIA The Best infertility specialists in India are globally popular for their expertise, comprehensive training and worldwide global experience. These infertility Doctors in India have had a profound impact on fertility research. The...

    Complete Guide to ICSI IVF

    What is ICSI Intracytoplasmic Sperm Injection? For individuals facing infertility, ICSI is a specialized form of IVF that significantly increases pregnancy chances, especially with male infertility concerns. ICSI procedure involves directly injecting a single sperm...


    Polycystic Ovary Syndrome (PCOS) is a common yet often misunderstood condition, affecting approximately 1 in 10 women of reproductive age worldwide. Characterized by a combination of symptoms that can include irregular menstrual cycles, excess androgen levels, and...


    FOREWORD | CUTTING EDGE FERTILITY TREATMENTS Infertility has emerged as a significant global health issue which is known to affect approximately 10-15% of couples worldwide. In the past decade, India has become a premier destination for fertility treatments for...

    Female Infertility Causes and Treatment

    Little Angel IVF: Unveiling the Mysteries of Female Infertility - Causes and Treatment Insights Female Infertility Causes and Treatment here - Embarking on the journey of parenthood can be challenging, especially when faced with the complexities of female infertility....

    Affordable IVF Cost in India for Families

    IVF, while intricate and costly is more affordable in India compared to Western countries, making it a popular destination for medical tourism. The cost of IVF in India varies based on factors like age, fertility issues, medical history and the number of cycles...

    HSG Tests in Noida

    HSG TESTS IN NOIDA Hysterosalpingography (HSG) is a vital diagnostic tool in the realm of female fertility evaluation. Little Angel IVF stands as a recognized name for conducting HSG tests in Noida with precision and care. An HSG test is a specialized X-ray procedure...

    Who is the best doctor for Infertility Treatment in India

    WHICH DOCTOR IS BEST FOR INFERTILITY TREATMENT IN INDIA Dr. Mona Dahiya is a renowned and highly respected medical professional specializing in the field of infertility treatment. With her vast knowledge, expertise, and compassionate approach, Dr. Dahiya has gained...