Mini IVF: Benefit, Success Rate & Cost

by | Sep 12, 2023 | IVF

What is Mini IVF?

Minimal Simulation (Mini) IVF is a specialized fertility treatment that offers a more gentle and less aggressive alternative to traditional IVF (In Vitro Fertilization). It is designed for individuals or couples who may not require or prefer high doses of fertility medications, yet still wish to pursue assisted reproductive techniques to achieve pregnancy.

 

Who Should Consider Mini IVF?

Mini IVF is a suitable option for various groups of individuals or couples, depending on their specific circumstances and preferences. Here are some scenarios where Mini IVF might be considered:

  1. Lower Ovarian Reserve: Individuals with a lower ovarian reserve, which means they have fewer eggs in their ovaries, may opt for Mini IVF as it aims to retrieve a smaller number of eggs without the need for excessive ovarian stimulation.
  2. Reduced Ovarian Response: Some women do not respond well to high doses of fertility medications used in traditional IVF. For these individuals, Mini IVF offers a milder approach with lower medication doses.
  3. Health Concerns: Women with certain health conditions that contraindicate the use of high-dose fertility drugs may choose Mini IVF as a safer alternative.
  4. Previous Poor Response: Couples who have undergone multiple cycles of traditional IVF with poor results may explore Mini IVF to reduce the physical and emotional stress associated with the treatment.
  5. Cost Considerations: Mini IVF can be more cost-effective compared to traditional IVF, making it an attractive option for those who are concerned about the financial aspects of fertility treatment.
  6. Preference for Minimal Intervention: Some individuals or couples prefer a more natural approach to fertility treatment and are drawn to Mini IVF’s reduced medication and intervention levels.

 

Mini IVF Process Step-by-Step

Mini IVF involves a series of steps similar to traditional IVF but with differences in medication dosages and ovarian stimulation. Here’s a step-by-step guide to the Mini IVF process:

  1. Initial Consultation: The journey begins with an initial consultation with a fertility specialist. During this visit, the medical team will review your medical history, conduct necessary tests, and discuss your fertility goals to determine if Mini IVF is the right option for you.
  2. Ovarian Stimulation: Unlike traditional IVF, where high doses of fertility medications are used to stimulate the ovaries and produce a large number of eggs, Mini IVF employs lower doses of medications. These medications encourage the growth of a smaller cohort of follicles.
  3. Monitoring: Throughout the ovarian stimulation phase, your fertility team will monitor your progress through blood tests and ultrasound scans. This monitoring helps adjust medication dosages as needed.
  4. Egg Retrieval: Once the follicles have reached an appropriate size, a trigger shot of hCG (human chorionic gonadotropin) is administered to induce the final maturation of the eggs. Approximately 36 hours later, a minimally invasive procedure called egg retrieval is performed to collect the mature eggs. This procedure is typically done under sedation.
  5. Fertilization: The retrieved eggs are then fertilized with sperm in the laboratory through either conventional insemination or intracytoplasmic sperm injection (ICSI), depending on the specific circumstances.
  6. Embryo Culturing: The resulting embryos are cultured in the laboratory for several days (usually 3 to 5 days) to allow for their development and growth.
  7. Embryo Transfer: In Mini IVF, the focus is on quality over quantity. Only a limited number of the healthiest embryos are selected for transfer into the uterus. This reduces the risk of multiple pregnancies.
  8. Luteal Phase Support: To support the implantation and early stages of pregnancy, hormonal medications may be prescribed.
  9. Pregnancy Test: Approximately 10 to 14 days after the embryo transfer, a blood test is performed to determine if pregnancy has been achieved.

 

Benefits of Mini IVF

  1. Reduced Medication and Side Effects: One of the primary benefits of Mini IVF is the use of lower doses of fertility medications. This leads to fewer side effects and a reduced risk of ovarian hyperstimulation syndrome (OHSS), making it a more comfortable option for many patients.
  2. Less Invasive: Mini IVF is a less invasive procedure compared to traditional IVF, as it involves minimal ovarian stimulation. This can result in fewer injections and less monitoring, making the process less physically demanding.
  3. Cost-Effective: Mini IVF can be more cost-effective than traditional IVF, as it requires fewer medications and monitoring visits. This makes it a viable option for couples who may have budget constraints.
  4. Suitable for Specific Cases: Mini IVF may be a better option for individuals or couples with lower ovarian reserves or those who have not responded well to high-dose fertility medications in the past.
  5. Reduced Risk of Multiple Pregnancies: Because Mini IVF typically results in the retrieval of fewer eggs and the transfer of fewer embryos, there is a reduced risk of multiple pregnancies, which are associated with higher health risks.

 

Risks of Mini IVF

  1. Lower Egg Yield: Since Mini IVF aims to retrieve a smaller number of eggs, there may be a reduced chance of having surplus embryos for freezing or future use.
  2. Lower Success Rates for Some Cases: For individuals with specific fertility issues that require a higher number of eggs or embryos for successful fertilization, Mini IVF may have lower success rates compared to traditional IVF.
  3. No Guarantee of Success: As with any fertility treatment, there are no guarantees of pregnancy success, and multiple treatment cycles may be necessary.
  4. Limited Options for Genetic Testing: Mini IVF may not yield enough embryos for comprehensive genetic testing, which is important for some individuals or couples with known genetic conditions.
  5. Not Suitable for Severe Infertility Cases: In cases of severe infertility where a more aggressive approach is required, Mini IVF may not be the most appropriate option.

 

Success Rate of Mini IVF in Noida, India

In Noida, success rates for Mini IVF could range from approximately 10% to 30%, although this can vary significantly from one clinic to another. It’s important to note that success rates are typically reported as the percentage of cycles that result in a live birth. For individuals or couples considering Mini IVF, it’s essential to consult with a fertility specialist who can provide personalized guidance based on their specific circumstances.

Success rates of Mini IVF can vary widely depending on several factors, including the patient’s age, fertility diagnosis, and the clinic’s expertise. Mini IVF generally has slightly lower success rates compared to traditional IVF. In Noida, success rates may also differ between clinics.

 

Cost of Mini IVF in Noida, India

The cost of Mini IVF in Noida is generally lower than that of traditional IVF due to reduced medication and monitoring requirements. The cost of Mini IVF in Noida could range from approximately ₹ 60,000 to ₹ 120,000 per IVF cycle. However, the exact cost can vary depending on the clinic’s location, reputation, and the specific services included.

 

Mini IVF After Tubal Ligation:

Tubal ligation, commonly known as “getting your tubes tied,” is a surgical procedure for permanent contraception. It involves the sealing or cutting of the fallopian tubes, making it highly effective in preventing pregnancy. However, some individuals who have undergone tubal ligation may later decide they want to have a child. In such cases, Mini IVF can offer a potential solution.

 

How Mini IVF after Tubal Ligation Works?

Mini IVF after tubal ligation is a fertility treatment that involves bypassing the blocked or sealed fallopian tubes to achieve pregnancy through in vitro fertilization. Here’s how it typically works:

  1. Ovarian Stimulation: The woman undergoing Mini IVF will receive a milder ovarian stimulation regimen compared to conventional IVF. This aims to produce a limited number of high-quality eggs while avoiding overstimulation.
  2. Egg Retrieval: Once the eggs are mature, they are retrieved through a minimally invasive procedure, similar to other IVF procedures.
  3. Fertilization: The retrieved eggs are fertilized with sperm in the laboratory to create embryos.
  4. Embryo Transfer: Instead of attempting to pass the fertilized embryo through the fallopian tubes, as in a natural pregnancy, the resulting embryos are directly transferred into the uterus. This process bypasses the blocked or sealed tubes.
  5. Luteal Phase Support: Hormonal medications may be prescribed to support the uterine lining and improve the chances of successful implantation.
  6. Monitoring and Pregnancy Test: The patient is closely monitored throughout the process, and a pregnancy test is conducted to determine if implantation has occurred.

It’s important to note that while Mini IVF can be an option for individuals after tubal ligation, it may not be suitable for everyone, and success rates can vary. Consultation with a fertility specialist is crucial to assess the feasibility of Mini IVF in such cases.

 

Difference Between Mini IVF & Conventional IVF:

Mini IVF vs conventional IVF are both assisted reproductive techniques, but they differ in several key aspects:

  1. Medication Dosage:
  • Mini IVF: Involves using lower doses of fertility medications to stimulate the ovaries gently.
  • Conventional IVF: Utilizes higher doses of medications to stimulate the ovaries, aiming for the production of multiple eggs.
  1. Egg Retrieval:
  • Mini IVF: Typically results in the retrieval of a smaller number of eggs (1-5), focusing on quality over quantity.
  • Conventional IVF: Aims to retrieve a larger number of eggs (usually more than 10) to maximize the chances of successful fertilization.
  1. Cost:
  • Mini IVF: Generally, costs less than conventional IVF due to reduced medication and monitoring expenses.
  • Conventional IVF: Tends to be more expensive because of the higher medication and monitoring costs.
  1. Risk of Ovarian Hyperstimulation Syndrome (OHSS):
  • Mini IVF: Carries a lower risk of OHSS due to the mild stimulation approach.
  • Conventional IVF: Has a higher risk of OHSS, especially in individuals who are more sensitive to fertility medications.
  1. Success Rates:
  • Mini IVF: May have slightly lower success rates compared to conventional IVF, particularly for certain patient groups.
  • Conventional IVF: Generally, has higher success rates, making it a preferred choice for individuals with more complex infertility issues.

 

Difference Between Mini IVF, Mild IVF & Micro IVF:

Mini-IVF, mild IVF, and micro-IVF are variations of IVF treatment, each with its own unique characteristics:

  1. Medication Intensity:
  • Mini IVF: Uses lower doses of fertility medications compared to conventional IVF but is still designed to produce a limited number of high-quality eggs.
  • Mild IVF: Involves a moderate amount of medication to stimulate the ovaries, resulting in a slightly higher egg yield compared to Mini IVF.
  • Micro IVF: Uses minimal or no fertility medications, relying on the natural menstrual cycle or very mild stimulation. This typically results in the retrieval of only one or a very small number of eggs.
  1. Egg Retrieval:
  • Mini IVF: Aims for a modest number of eggs, typically between 1-5, emphasizing quality.
  • Mild IVF: Targets a slightly higher egg yield compared to Mini IVF but still seeks to balance quality and quantity.
  • Micro IVF: Retrieves a minimal number of eggs, often just one or two, making it the most conservative option.
  1. Cost:
  • Mini IVF: Offers cost savings compared to conventional IVF but may be slightly more expensive than micro IVF due to the use of some medications.
  • Mild IVF: Typically falls in the mid-range in terms of cost, as it involves a moderate amount of medication.
  • Micro IVF: This is often the most cost-effective option due to minimal medication use and reduced monitoring.
  1. Suitability:
  • Mini IVF: Suitable for individuals who prefer a gentler approach or have specific fertility issues that benefit from limited stimulation.
  • Mild IVF: Appropriate for a broader range of patients, including those with moderate infertility concerns.
  • Micro IVF: Best suited for individuals who want the least invasive option or have very mild fertility issues.

 

Conclusion

Mini IVF offers a gentler and more cost-effective approach to assisted reproductive technology for individuals or couples who may not require or prefer the intensity of traditional IVF. By using lower medication dosages and focusing on quality rather than quantity, Mini IVF can be a suitable option for those with specific medical conditions, lower ovarian reserves, or cost concerns. Ultimately, the decision to pursue Mini IVF should be made in consultation with a fertility specialist who can provide personalized guidance based on individual circumstances and goals.

 

F.A.Q

Q: Is Mini IVF Painful?

A: Mini IVF, like traditional IVF, involves some discomfort, but it’s generally not considered painful. Patients may experience mild discomfort during the egg retrieval procedure, which is typically managed with anesthesia or pain medication. The level of discomfort varies from person to person, but it is usually manageable.

Q: Who benefits from mini IVF?

A: Mini IVF is particularly beneficial for women who may not respond well to high doses of fertility medications or those who want a less invasive and more cost-effective fertility treatment option. It’s also suitable for women with certain medical conditions where multiple eggs are not advisable.

Q: Is mini IVF better than IUI?

A: The choice between mini IVF and intrauterine insemination (IUI) depends on individual circumstances. Mini IVF typically has higher success rates than IUI but is also more invasive and costly. The best option varies based on factors like age, fertility diagnosis, and patient preferences.

Q: What is the cost of mini IVF in India?

A: The cost of mini IVF in India can vary widely depending on the clinic, location, and specific treatment plan. On average, it may cost significantly less than traditional IVF, making it a more affordable option for many couples. Costs typically include medications, monitoring, and the procedure itself.

Q: Is Mini IVF safe?

A: Mini IVF is generally considered safe when performed by experienced medical professionals. Like any medical procedure, it carries some risks, such as ovarian hyperstimulation syndrome and multiple pregnancies. However, the reduced use of fertility medications in mini IVF may lower the risk of certain complications compared to traditional IVF.

Q: Does 100% IVF work?

A: There is no such thing as 100% guaranteed success in IVF or any fertility treatment. Success rates vary depending on factors like age, overall health, and the specific fertility issue being addressed. While IVF has helped many couples achieve pregnancy, success is not guaranteed for every individual.

Q: How many injections for mini IVF?

A: The number of injections required for mini IVF varies from person to person and depends on the treatment plan prescribed by the fertility specialist. Typically, patients receive fewer injections in mini IVF compared to traditional IVF because the goal is to produce fewer but high-quality eggs.

Q: Which type of IVF is best?

A: The choice between mini IVF, traditional IVF, or other fertility treatments depends on individual circumstances and preferences. There is no one-size-fits-all answer. A fertility specialist can assess a patient’s unique situation and recommend the most suitable treatment option.

Q: What are the 3 types of IVF?

A: The three main types of IVF are traditional IVF, mini IVF, and natural cycle IVF. Traditional IVF involves high doses of fertility medications, mini IVF uses lower doses and natural cycle IVF relies on a woman’s natural menstrual cycle without medication to stimulate egg production.

Q: How long is mini IVF?

A: The duration of a mini IVF cycle can vary, but it typically takes about 2-4 weeks from the start of medication to the embryo transfer. This timeline may vary depending on the specific treatment plan and the patient’s response to medications. The entire process, from consultation to pregnancy test, can take several months.

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    Dr Mona Dahiya

    Dr Mona Dahiya

    IVF Specialist & Consultant

    Dr Mona Dahiya has performed over 10,000+ IVF cycles and is considered a global expert in IVF, ICSI, IUI and male fertility treatment. She is an eminent writer on Infertility Treatment and has over 100 Publications in both International and National Journals. Dr Mona Dahiya has immensely contributed to the field of infertility through her Research and articles.

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