Natural Cycle IVF: Success Rate, Procedure & Cost

by | Sep 19, 2023 | IVF

What is Natural Cycle IVF?

Natural Cycle IVF is a specialized form of in vitro fertilization that prioritizes minimal medical intervention. Unlike conventional IVF, which typically involves stimulating the ovaries with fertility drugs to produce multiple eggs, Natural Cycle IVF relies on a woman’s natural menstrual cycle to retrieve a single egg. This approach is well-suited for those who wish to avoid or are not suitable candidates for the rigorous hormone stimulation required in traditional IVF.


Can IVF be done naturally?

Yes, IVF can indeed be done naturally through Natural Cycle IVF. In this method, the reproductive specialists monitor a woman’s natural menstrual cycle and retrieve the one egg that her body naturally produces each month. This retrieved egg is then fertilized with sperm in a laboratory setting, similar to conventional IVF. The resulting embryo is subsequently transferred to the woman’s uterus in the hope of achieving pregnancy.


Who Should Do Natural Cycle IVF?

Natural Cycle IVF is not for everyone, but it can be a suitable choice for specific individuals or couples based on their fertility profiles and personal preferences. Here are some scenarios where Natural Cycle IVF may be a viable option:

  1. Minimal Ovarian Reserve: Women with a low ovarian reserve, meaning they produce very few eggs, may opt for Natural Cycle IVF as it requires minimal stimulation and relies on the natural production of eggs.
  2. Hormone Sensitivities: Some women may have medical conditions or sensitivities that make them unsuitable candidates for the high doses of hormones used in traditional IVF. Natural Cycle IVF provides a gentler alternative.
  3. Previous Failed IVF Cycles: Individuals who have experienced repeated failures with conventional IVF may consider Natural Cycle IVF as an alternative approach.
  4. Ethical or Religious Concerns: Some people have ethical or religious objections to the production and potential wastage of multiple embryos, which is more common in traditional IVF. Natural Cycle IVF can be a more ethically aligned option.
  5. Desire for Minimal Intervention: Couples who prefer a less invasive and drug-free approach to fertility treatment may choose Natural Cycle IVF.


Natural Cycle IVF Procedure

The Natural Cycle IVF procedure is a carefully timed process that aligns with a woman’s natural menstrual cycle. Here is an overview of the steps involved:

  1. Baseline Assessment: The process begins with a thorough evaluation of the woman’s menstrual cycle and ovarian reserve through blood tests and ultrasounds.
  2. Cycle Monitoring: Once the natural menstrual cycle is identified, the woman’s hormone levels and follicle development are monitored regularly to pinpoint the optimal time for egg retrieval.
  3. Egg Retrieval: When the leading follicle is mature, a minor surgical procedure known as transvaginal ultrasound-guided follicle aspiration is performed to retrieve the single egg.
  4. Fertilization: The retrieved egg is then fertilized with sperm in the laboratory to create an embryo.
  5. Embryo Transfer: The resulting embryo is cultured and monitored for development. Once ready, a single embryo is transferred into the woman’s uterus, typically two to five days after fertilization.
  6. Pregnancy Test: A pregnancy test is conducted about ten to fourteen days after the embryo transfer to determine if the procedure was successful.
  7. Supportive Medications (Optional): In some cases, hormonal support through medications like progesterone may be recommended to assist with embryo implantation.

It’s important to note that the success rates of Natural Cycle IVF may be lower than traditional IVF, as it relies on a single egg. However, it offers a more natural and less physically demanding experience for the patient.


Natural Cycle IVF Benefits

  1. Minimally Invasive: One of the primary benefits of Natural Cycle IVF is that it minimizes the use of fertility drugs, making it less invasive than traditional IVF. This approach aligns with a woman’s natural menstrual cycle, reducing the risk of ovarian hyperstimulation syndrome (OHSS) and other potential side effects associated with hormonal stimulation.
  2. Ethical and Religious Alignment: Natural Cycle IVF is often preferred by individuals and couples who have ethical or religious objections to the production and potential wastage of multiple embryos. Since it typically yields only one egg per cycle, it aligns better with their beliefs.
  3. Lower Medication Costs: As Natural Cycle IVF relies on the natural production of a single egg, it requires fewer fertility medications. This can result in lower medication costs compared to traditional IVF, which necessitates higher doses of hormones.
  4. Reduced Physical Discomfort: Traditional IVF can be physically demanding due to the hormonal injections required for ovarian stimulation. Natural Cycle IVF eliminates or reduces this discomfort, making it a more comfortable option for some patients.
  5. Personalized Approach: Natural Cycle IVF allows for a more personalized and patient-centric approach, as it considers an individual’s unique natural cycle and hormone levels. This can lead to a more tailored treatment plan.


Natural Cycle IVF Success Rate in India

The success of Natural Cycle IVF can vary from one individual to another and depends on several factors, including age, overall health, and the specific fertility issues being addressed. In India, as in other countries, the success rates for Natural Cycle IVF tend to be lower compared to traditional IVF. However, it’s essential to note that success rates can differ between fertility clinics and may improve with advancements in technology and expertise. Here are some factors influencing the success rate:

  1. Age: Age plays a significant role in the success of Natural Cycle IVF. Younger individuals generally have a higher chance of success because they tend to have healthier eggs.
  2. Ovarian Reserve: The quantity and quality of a woman’s eggs, known as ovarian reserve, can impact success rates. Individuals with a good ovarian reserve may have a higher likelihood of success.
  3. Sperm Quality: The quality of the sperm used for fertilization is equally important. High-quality sperm can increase the chances of a successful embryo development.
  4. Expertise of the Fertility Clinic: The experience and proficiency of the fertility clinic and its staff in performing Natural Cycle IVF procedures can influence success rates. Choosing a reputable clinic with a track record of successful outcomes is crucial.
  5. Previous Fertility History: A person’s fertility history, including previous pregnancies and miscarriages, can also impact the success of Natural Cycle IVF.

It’s essential for individuals and couples considering Natural Cycle IVF to consult with a fertility specialist who can assess their specific situation and provide personalized information regarding expected success rates.


Natural Cycle IVF Cost in India

The cost of Natural Cycle IVF in India can vary widely depending on several factors, including the geographical location, the reputation of the fertility clinic, and the individual’s specific needs. However, when compared to traditional IVF, Natural Cycle IVF is generally considered more cost-effective due to the reduced need for fertility medications. Here’s a breakdown of the typical costs associated with Natural Cycle IVF in India:

  1. Initial Consultation: The process begins with an initial consultation with a fertility specialist. This usually incurs a fee, which can vary from clinic to clinic.
  2. Monitoring and Testing: Throughout the treatment cycle, there will be regular monitoring, including ultrasounds and blood tests. These costs are typically included in the overall package.
  3. Egg Retrieval: The procedure for egg retrieval is another significant cost component. The cost may vary depending on the clinic and location.
  4. Fertilization and Culture: The laboratory procedures, including fertilization of the egg and embryo culture, are also included in the cost.
  5. Embryo Transfer: The cost of transferring the resulting embryo into the uterus is part of the overall package.
  6. Medications: While Natural Cycle IVF requires fewer medications than traditional IVF, there may still be some medication costs associated with the treatment.
  7. Additional Services: Some clinics offer additional services, such as genetic testing of embryos, at an additional cost.

It’s crucial to obtain a detailed breakdown of costs from the chosen fertility clinic to understand the full financial commitment. Additionally, individuals should inquire about any potential additional fees that may arise during the course of treatment.


Natural Cycle IVF vs. Conventional IVF

  1. Ovarian Stimulation:
  • Natural Cycle IVF: In Natural Cycle IVF, ovarian stimulation is intentionally minimized or entirely avoided. The focus is on retrieving the one naturally occurring egg produced during a woman’s menstrual cycle. This makes the procedure less physically demanding in terms of hormone injections.
  • Conventional IVF: Conventional IVF involves rigorous ovarian stimulation using fertility drugs to induce the production of multiple eggs. This process is more invasive and requires frequent monitoring of hormone levels.
  1. Egg Retrieval:
  • Natural Cycle IVF: Egg retrieval in Natural Cycle IVF is typically less complex and may involve fewer risks compared to Conventional IVF. Since only one egg is targeted, the procedure can be simpler.
  • Conventional IVF: In Conventional IVF, the goal is to retrieve multiple eggs, which requires a more invasive procedure and carries a slightly higher risk of complications.
  1. Ethical Considerations:
  • Natural Cycle IVF: Natural Cycle IVF is often chosen by individuals or couples who have ethical or religious concerns about producing and potentially discarding multiple embryos. It aligns better with their values since it typically results in just one embryo.
  • Conventional IVF: Conventional IVF can produce multiple embryos, some of which may not be used, leading to ethical dilemmas for certain individuals.
  1. Success Rates:
  • Natural Cycle IVF: Success rates for Natural Cycle IVF tend to be lower compared to Conventional IVF because it relies on a single egg. However, it can still be a viable option for specific individuals with particular fertility issues.
  • Conventional IVF: Conventional IVF generally has higher success rates due to the availability of multiple embryos for selection and transfer. This makes it the preferred choice for those with more severe fertility challenges.
  1. Cost:
  • Natural Cycle IVF: Natural Cycle IVF is often considered more cost-effective than Conventional IVF because it requires fewer fertility medications and monitoring sessions.
  • Conventional IVF: Conventional IVF can be more expensive due to the higher medication costs and more intensive monitoring required.
  1. Physical Discomfort:
  • Natural Cycle IVF: Natural Cycle IVF is generally less physically uncomfortable compared to Conventional IVF since it avoids the side effects associated with ovarian stimulation. However, the egg retrieval procedure can still cause some discomfort.
  • Conventional IVF: The hormone injections used in Conventional IVF for ovarian stimulation can lead to side effects such as bloating, mood swings, and discomfort. The egg retrieval procedure may also be more uncomfortable.


Natural Cycle IVF vs. Needle-Free IVF

  1. Ovarian Stimulation:
  • Natural Cycle IVF: Natural Cycle IVF minimizes or avoids ovarian stimulation altogether, making it needle-free in terms of hormone injections.
  • Needle-Free IVF: Needle-Free IVF, as the name suggests, also eliminates the need for hormone injections, making it less invasive in terms of medication administration.
  1. Egg Retrieval:
  • Natural Cycle IVF: Egg retrieval in Natural Cycle IVF still involves a minor surgical procedure, which may require a needle for aspiration.
  • Needle-Free IVF: Needle-Free IVF eliminates the need for egg retrieval through invasive procedures. Instead, it relies on non-invasive techniques, such as transvaginal ultrasound-guided follicle aspiration or other innovative approaches.
  1. Ethical Considerations:
  • Natural Cycle IVF: Like Conventional IVF, Natural Cycle IVF may produce multiple embryos, which can raise ethical concerns for some individuals.
  • Needle-Free IVF: Needle-Free IVF, by design, avoids the creation of multiple embryos, which can be an appealing factor for those with ethical or religious objections to discarding unused embryos.
  1. Success Rates:
  • Natural Cycle IVF: Success rates for Natural Cycle IVF tend to be lower due to the reliance on a single egg.
  • Needle-Free IVF: Success rates for Needle-Free IVF can vary but are generally competitive with Conventional IVF since it still allows for the retrieval of multiple eggs without using traditional hormone injections.
  1. Cost:
  • Natural Cycle IVF: As mentioned earlier, Natural Cycle IVF can be cost-effective due to lower medication expenses.
  • Needle-Free IVF: The cost of Needle-Free IVF can vary depending on the specific technique used, but it may be comparable to or slightly more expensive than Conventional IVF due to the advanced technology involved.


Is Natural Cycle IVF Painful?

Whether Natural Cycle IVF is painful can vary from person to person and may depend on individual pain tolerance. Here are some aspects to consider:

  • Egg Retrieval: The most potentially uncomfortable part of Natural Cycle IVF is the egg retrieval procedure. This procedure involves the insertion of a needle through the vaginal wall to aspirate the mature egg from the ovarian follicle. While discomfort is possible, it is generally well-tolerated with the use of local anesthesia or sedation. Most patients describe it as a brief, mild discomfort rather than intense pain.
  • Hormonal Stimulation: One of the benefits of Natural Cycle IVF is the reduced use of fertility medications, which can contribute to discomfort and bloating in Conventional IVF. However, Natural Cycle IVF still involves some monitoring and medication use, which may cause mild discomfort for some individuals.
  • Individual Variability: Pain perception varies widely among individuals. Some people may experience more discomfort during procedures like egg retrieval, while others may find it relatively painless. It’s essential to communicate any concerns or discomfort with the medical team, who can take steps to minimize pain through anesthesia or pain management.


In conclusion, Natural Cycle IVF is a unique approach to assisted reproduction that prioritizes minimal medical intervention and aligns with a woman’s natural cycle. While it may not be suitable for everyone, it provides a valuable option for individuals and couples seeking a more gentle and less invasive alternative to traditional IVF. The decision to pursue Natural Cycle IVF should be made in consultation with a fertility specialist who can assess individual circumstances and provide personalized recommendations.

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    Dr Mona Dahiya

    Dr Mona Dahiya

    IVF Specialist & Consultant

    Dr Mona Dahiya has performed over 5,000+ IVF cycles and is considered a global expert in IVF, ICSI, IUI and male fertility treatment. She is an eminent writer on Infertility Treatment and has over 100 Publications in both International and National Journals. Dr Mona Dahiya has immensely contributed to the field of infertility through her Research and articles.

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