Best Treatment for Unexplained Infertility

by | Jul 28, 2023 | Fertility

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What is Unexplained Infertility?

Unexplained infertility is a term used when couples cannot conceive despite undergoing a comprehensive fertility evaluation. Typically, both partners are deemed physically healthy, with no apparent issues impacting their ability to conceive. Doctors rule out common causes such as ovulation disorders, fallopian tube blockages, or sperm abnormalities. It is akin to a perplexing puzzle without any visible clues, leaving both medical professionals and couples baffled.


How Common is Unexplained Infertility?

Statistics show that approximately 15% to 25% of infertile couples receive this diagnosis. While it offers some relief to know that you are not alone, it doesn’t alleviate the frustration of not having a clear answer as to why conception remains elusive.


Is Pregnancy Possible with Unexplained Infertility?

YES! Even though the underlying cause remains elusive, many couples do achieve pregnancy despite unexplained infertility. The human body is remarkably complex, and sometimes, even medical science cannot explain certain phenomena. Couples who persevere and maintain a positive outlook increase their chances of conceiving.


How to Get Pregnant with Unexplained Infertility?

While navigating unexplained infertility may feel like trying to navigate a maze in the dark, there are steps couples can take to enhance their chances of conception.

  1. Embrace a Healthy Lifestyle: A healthy lifestyle lays a strong foundation for conception. Incorporate nutritious foods, regular exercise, and stress-reduction techniques into your daily routine. Remember, self-care isn’t selfish; it’s an investment in your future family.
  2. Timing is Everything: Understanding your menstrual cycle and identifying the fertile window is crucial. Tracking ovulation through charting basal body temperature or using ovulation predictor kits can optimize the chances of conceiving.
  3. Seek Professional Guidance: Consulting with a reproductive specialist can provide invaluable insights and personalized strategies for conception. Fertility treatments like intrauterine insemination (IUI) or in vitro fertilization (IVF) could be considered if appropriate.
  4. Stay Positive and Relaxed: Maintaining a positive mindset and reducing stress is easier said than done. Engage in activities that bring you joy, practice mindfulness, and explore relaxation techniques like yoga or meditation.


Causes of Unexplained Infertility:

While the exact reasons behind unexplained infertility remain elusive, several factors might contribute to this condition:

  1. Subtle Imbalances in Reproductive Hormones: Even minor disruptions in hormone levels can affect ovulation and fertilization, making it challenging to conceive.
  2. Sperm-Immune Interaction: In some cases, the female partner’s immune system may mistakenly attack and damage sperm, hindering successful fertilization.
  3. Egg Quality: Poor egg quality can reduce the chances of successful conception, even in the absence of any apparent issues with the reproductive system.
  4. Genetic Factors: There could be underlying genetic factors that impact fertility, but they may not be easily detectable through standard tests.
  5. Lifestyle and Environmental Factors: Unhealthy lifestyle habits, exposure to environmental toxins, and excessive stress can all influence fertility.


Symptoms of Unexplained Infertility:

Unexplained infertility is unique in that it does not present any specific symptoms itself. Couples may have been trying to conceive for a significant period without success, leading them to seek medical assistance. In such cases, the absence of pregnancy despite regular, unprotected intercourse is the primary indicator of unexplained infertility.


Diagnosing Unexplained Infertility:

The diagnosis of unexplained infertility involves a comprehensive assessment of both partners’ reproductive health. The following steps are typically involved in the diagnostic process:

  1. Medical History and Physical Examination: The healthcare provider will review the couple’s medical history and perform a physical examination to identify any potential issues.
  2. Ovulation Tracking: Ovulation tests and tracking basal body temperature can help determine if the female partner is ovulating regularly.
  3. Semen Analysis: A semen analysis is conducted to assess the quantity and quality of sperm produced by the male partner.
  4. Hysterosalpingogram (HSG): This imaging test evaluates the condition of the uterus and fallopian tubes to ensure they are free from any blockages.
  5. Hormone Testing: Blood tests are conducted to check hormone levels, as imbalances can affect fertility.
  6. Ovarian Reserve Testing: Assessing the ovarian reserve helps gauge the quantity and quality of the female partner’s eggs.
  7. Laparoscopy (if necessary): In some cases, a surgical procedure called laparoscopy may be performed to check for any underlying issues in the reproductive organs.


Treatment Options for Unexplained Infertility:

Couples diagnosed with unexplained infertility are not left without hope. Several treatments can improve their chances of conception:

  1. Ovulation Induction: Ovulation-stimulating medications, such as clomiphene citrate or letrozole, can enhance the release of eggs, increasing the chances of pregnancy.
  2. Intrauterine Insemination (IUI): During IUI, washed and concentrated sperm is directly inserted into the uterus, bypassing potential cervical barriers.
  3. In Vitro Fertilization (IVF): IVF involves retrieving eggs from the female partner, fertilizing them with sperm in a laboratory, and transferring the resulting embryo(s) to the uterus.
  4. Intracytoplasmic Sperm Injection (ICSI): ICSI is used in conjunction with IVF, where a single sperm is directly injected into an egg to facilitate fertilization.
  5. Assisted Hatching: This technique involves creating a small opening in the outer shell (zona pellucida) of the embryo to facilitate implantation in the uterus.
  6. Preimplantation Genetic Testing (PGT): PGT helps identify chromosomally normal embryos before transferring them to the uterus, reducing the risk of miscarriage and improving implantation rates.
  7. Egg or Sperm Donor: If necessary, couples may opt for egg or sperm donation to increase the likelihood of successful fertilization and pregnancy.


Comparison of Unexplained InfertilityTreatment Success Rates:

Treatment Success Rate (%)
Ovulation Induction 15-20%
Intrauterine Insemination 15-20%
In Vitro Fertilization 40-50%
Intracytoplasmic Sperm Injection 60-65%
Egg/Sperm Donor 50-70%


Which is the Best Treatment for Unexplained Infertility?

IVF with ICSI generally yields higher success rates compared to other treatments for unexplained infertility. However, the choice of the best treatment for unexplained infertility varies from couple to couple and depends on various factors, including age, overall health, financial considerations, and previous medical history.


Can Unexplained Infertility Be Prevented?

Preventing unexplained infertility can be challenging since its exact causes are not well understood. However, several lifestyle changes and habits may enhance overall fertility health and increase the chances of conception:

  1. Maintain a Healthy Weight: Both partners should strive to maintain a healthy weight as obesity or being underweight can impact fertility.
  2. Healthy Diet: A balanced diet rich in nutrients, antioxidants, and vitamins can boost fertility.
  3. Regular Exercise: Engaging in regular physical activity can improve fertility and reduce stress.
  4. Quit Smoking and Limit Alcohol: Smoking and excessive alcohol consumption can negatively affect fertility.
  5. Manage Stress: Finding effective ways to manage stress, such as yoga, meditation, or hobbies, can positively impact fertility.
  6. Avoid Exposure to Toxins: Minimize exposure to harmful chemicals and environmental toxins that may affect fertility.


Tips for Conceiving with Unexplained Infertility:

Now that we’ve uncovered potential reasons for unexplained infertility, it’s time to take action. While there’s no guaranteed formula, several strategies can increase your chances of conceiving:

  1. Embrace a Healthy Lifestyle: Think of your body as a fertile garden where the seeds of life can thrive. Nurture it with nutrient-rich foods, regular exercise, and mindfulness practices to reduce stress. Embrace a holistic approach to fertility.
  2. Time Intimacy Strategically: When trying to conceive, timing is everything. Understanding your menstrual cycle and ovulation patterns can help maximize your chances. Consider using ovulation predictor kits or fertility apps to identify your fertile window.
  3. Consider Fertility Treatments: If natural methods prove insufficient, fertility treatments like intrauterine insemination (IUI) or in vitro fertilization (IVF) can offer hope. Consult with a qualified fertility specialist to explore these options.



Unexplained infertility may be shrouded in mystery, but it’s essential for couples to remember that there is always hope. By staying informed, embracing support, and exploring various options, couples can empower themselves on their journey to parenthood. Let us take solace in the fact that sometimes, the most profound mysteries of life are simply meant to unfold in their own time, with the promise of a beautiful and cherished outcome waiting on the horizon.



Q: What is the first treatment for unexplained fertility?

A: Initial treatment for unexplained fertility usually involves lifestyle adjustments and fertility medications.

Q: Can unexplained infertility be cured?

A: Unexplained infertility may not always have a definite cure, but it can be managed through various assisted reproductive techniques.

Q: What is the biggest reason for unexplained infertility?

A: The primary reason for unexplained infertility is often unknown, as conventional fertility tests do not reveal any specific cause.

Q: What is the most successful treatment for infertility?

A: The most successful treatment for infertility varies depending on individual cases, but in vitro fertilization (IVF) has shown high success rates for many couples.

Q: Is IVF good for unexplained infertility?

A: Yes, IVF can be a viable option for unexplained infertility as it bypasses potential unidentified issues and enhances the chances of conception.

Q: What is the success rate of unexplained infertility?

A: The success rate for treating unexplained infertility varies, but with advanced fertility treatments like IVF, the chances of successful conception can significantly improve.

Q: Is IUI effective for unexplained infertility?

A: Intrauterine insemination (IUI) can be effective for unexplained infertility when combined with fertility medications, increasing the likelihood of successful pregnancy. However, the effectiveness may vary from person to person.

Q: How can I overcome unexplained infertility naturally?

A: To naturally overcome unexplained infertility, one can focus on adopting a healthy lifestyle, including a balanced diet, regular exercise, stress reduction, and avoiding harmful habits.

Q: Why am I not getting pregnant if everything is normal?

A: If all fertility tests indicate normal results, there might be subtle factors affecting fertility that current medical tests cannot detect.

Q: How can I get pregnant with unknown infertility?

A: If facing unknown infertility, seeking medical advice from a fertility specialist is crucial to explore various assisted reproductive treatments tailored to individual needs.

Q: What are 4 causes for female infertility?

A: Four potential causes of female infertility include ovulation disorders, fallopian tube blockages, endometriosis, and uterine abnormalities.

Q: What are 5 causes of infertility?

A: Five common causes of infertility encompass both male and female factors, such as hormonal imbalances, age-related decline in fertility, sperm abnormalities, structural issues in reproductive organs, and lifestyle factors.

Q: What are 3 treatments commonly used for infertility?

A: Three frequently employed infertility treatments are in vitro fertilization (IVF), intrauterine insemination (IUI), and fertility medications to stimulate ovulation.

Q: What is better than IVF treatment?

A: The superiority of treatment depends on individual circumstances, but some couples may find success with other options like intracytoplasmic sperm injection (ICSI) or using a gestational surrogate.

Q: What are the three main treatments for infertility?

A: The three primary infertility treatments are assisted reproductive technologies like IVF and ICSI, fertility medication to enhance ovulation, and surgical interventions to address structural issues.

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    Dr Mona Dahiya

    Dr Mona Dahiya

    IVF Specialist & Consultant

    Dr Mona Dahiya has performed over 5,000+ IVF cycles and is considered a global expert in IVF, ICSI, IUI and male fertility treatment. She is an eminent writer on Infertility Treatment and has over 100 Publications in both International and National Journals. Dr Mona Dahiya has immensely contributed to the field of infertility through her Research and articles.

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