4 Fertility Treatment Other Than IVF You Can Consider

by | Jul 1, 2021 | Fertility

4 Fertility Treatment Other Than IVF Are:

  1. Ovarian Stimulation Medications
  2. Intrauterine Insemination (IUI)
  3. Laparoscopy
  4. Intracytoplasmic Sperm Injection (ICSI)

Further we have explained all four fertility treatment options:

 

1. Ovarian Stimulation Medications:

Ovarian stimulation medications are medications that are used to stimulate the ovaries to produce multiple eggs in a single menstrual cycle. These medications are used in infertility treatments, such as in vitro fertilization (IVF), intrauterine insemination (IUI), and other assisted reproductive technologies (ART). The goal of ovarian stimulation is to increase the number of eggs available for fertilization and thereby increase the chances of pregnancy.

There are several types of ovarian stimulation medications, including:

  • Clomiphene citrate: This medication is an oral medication that is typically used to stimulate ovulation in women who do not ovulate regularly. It works by blocking the action of estrogen in the body, which in turn stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. These hormones stimulate the growth and maturation of ovarian follicles, which contain the eggs.
  • Gonadotropins: These medications are injectable medications that contain FSH and/or LH. They are used to stimulate the growth and maturation of ovarian follicles. Gonadotropins are typically used in women who have not responded to clomiphene citrate or who need more aggressive stimulation.
  • Letrozole: This medication is an oral medication that is sometimes used in place of clomiphene citrate. It works by inhibiting the production of estrogen in the body, which in turn stimulates the release of FSH and LH.
  • GnRH agonists and antagonists: These medications are used to prevent premature ovulation during ovarian stimulation. They work by suppressing the production of FSH and LH from the pituitary gland.

 

Treatment Procedure of Ovarian Stimulation Medications:

The treatment procedure of ovarian stimulation medications involves several steps:

  • Baseline evaluation: Before starting ovarian stimulation medications, a baseline evaluation is done to assess the woman’s ovarian reserve, hormone levels, and overall health. This evaluation typically includes a pelvic ultrasound, blood tests, and a medical history review.
  • Medication administration: Ovarian stimulation medications are typically given for 8-14 days, depending on the medication and the woman’s response to treatment. Medications are usually given by injection, either subcutaneously (under the skin) or intramuscularly (into the muscle).
  • Monitoring: During ovarian stimulation, the woman’s hormone levels and follicle growth are monitored closely through blood tests and pelvic ultrasounds. This monitoring helps to ensure that the medications are working properly and that the woman is not at risk for developing ovarian hyperstimulation syndrome (OHSS), a potentially serious complication of ovarian stimulation.
  • Trigger shot: Once the follicles have reached a certain size and the hormone levels are appropriate, a trigger shot is given to stimulate ovulation. The trigger shot typically contains human chorionic gonadotropin (HCG), a hormone that mimics LH and triggers ovulation within 36-40 hours.
  • Egg retrieval: About 36 hours after the trigger shot, the woman undergoes a procedure called egg retrieval. During this procedure, a needle is inserted through the vagina and into the ovaries to aspirate the mature follicles. The eggs are then removed from the follicles and fertilized in the laboratory.
  • Embryo transfer: After fertilization, the embryos are cultured for a few days before being transferred to the woman’s uterus. Embryo transfer is typically done 3-5 days after egg retrieval.

 

Success rate of Ovarian Stimulation Medications in India:

The success rate of ovarian stimulation medications in India varies depending on several factors, including the woman’s age, the cause of infertility, and the type of infertility treatment being used. However, the success rate of ovarian stimulation medications in India is generally considered to be high.

According to a study published in the Indian Journal of Endocrinology and Metabolism, the overall pregnancy rate per cycle of ovarian stimulation with intrauterine insemination (IUI) was found to be 17.8%. The study also found that the pregnancy rate was highest in women under the age of 30 (24.3%) and lowest in women over the age of 40 (5.3%).

In another study published in the Journal of Human Reproductive Sciences, the success rate of ovarian stimulation with in vitro fertilization (IVF) was found to be 44.8%. The study also found that the success rate was higher in women under the age of 35 (55.8%) and lower in women over the age of 35 (31.6%).

It is important to note that success rates can vary depending on the clinic and the expertise of the medical team. It is also important to discuss the potential risks and benefits of ovarian stimulation medications with a qualified healthcare provider before starting treatment.

In conclusion, ovarian stimulation medications are an effective treatment option for infertility in India, with a generally high success rate. The treatment procedure involves several steps, including medication administration, monitoring, trigger shot, egg retrieval, and embryo transfer. It is important to consult with a qualified healthcare provider to determine the best course of treatment based on individual factors and medical history.

 

Benefits of Ovarian Stimulation Medications:

Ovarian stimulation medications offer several benefits for women who are struggling with infertility. Some of the benefits include:

  • Increased chances of pregnancy: Ovarian stimulation medications can increase the number of eggs available for fertilization, which can increase the chances of pregnancy.
  • Customized treatment: Ovarian stimulation medications can be customized to meet the specific needs of each woman. The type and dosage of medication can be adjusted based on factors such as age, ovarian reserve, and response to treatment.
  • Improved timing: Ovarian stimulation medications can help to improve the timing of ovulation, which can increase the chances of successful fertilization.
  • Non-invasive: Ovarian stimulation medications are a non-invasive treatment option for infertility, as compared to other treatments such as surgery.
  • Cost-effective: Ovarian stimulation medications are generally more cost-effective than other infertility treatments such as in vitro fertilization (IVF).

 

Risks of Ovarian Stimulation Medications:

While ovarian stimulation medications offer several benefits, there are also some risks associated with this treatment option. Some of the risks include:

  • Ovarian hyperstimulation syndrome (OHSS): OHSS is a potentially serious complication of ovarian stimulation medications that can cause the ovaries to become swollen and painful. Symptoms can include abdominal pain, bloating, and nausea. In severe cases, OHSS can cause fluid buildup in the chest and abdomen, which can be life-threatening.
  • Multiple pregnancies: Ovarian stimulation medications can increase the chances of multiple pregnancies, such as twins or triplets. Multiple pregnancies can increase the risk of complications during pregnancy and childbirth.
  • Ectopic pregnancy: Ovarian stimulation medications can increase the risk of ectopic pregnancy, which occurs when a fertilized egg implants outside of the uterus.
  • Birth defects: Some studies have suggested that there may be a slightly increased risk of birth defects in babies born as a result of ovarian stimulation medications.
  • Emotional stress: Infertility treatments can be emotionally stressful, and ovarian stimulation medications are no exception. The stress of treatment can impact a woman’s mental health and well-being.

It is important to discuss the potential risks and benefits of ovarian stimulation medications with a qualified healthcare provider before starting treatment.

 

Cost of Ovarian Stimulation Medications in India:

The cost of ovarian stimulation medications in India can vary depending on several factors, including the type of medication, the dosage, and the clinic or hospital where the treatment is being provided.

According to a report by the Times of India, the cost of ovarian stimulation medications in India can range from Rs. 5,000 to Rs. 15,000 per cycle, depending on the type of medication being used. The cost of other infertility treatments such as in vitro fertilization (IVF) can range from Rs. 1 lakh to Rs. 2 lakhs per cycle.

It is important to note that the cost of treatment can be impacted by additional factors such as the need for additional testing, monitoring, or procedures. It is also important to discuss the cost of treatment with a qualified healthcare provider and to explore options for financing or insurance coverage.

In conclusion, ovarian stimulation medications offer several benefits for women struggling with infertility, including increased chances of pregnancy and customized treatment. However, there are also some risks associated with this treatment option, including ovarian hyperstimulation syndrome and multiple pregnancies. The cost of ovarian stimulation medications in India can vary depending on several factors, and it is important to discuss the cost of treatment with a qualified healthcare provider.

 

2. Intrauterine Insemination (IUI):

Intrauterine insemination (IUI) is a fertility treatment that involves placing washed and concentrated sperm directly into a woman’s uterus at the time of ovulation. The goal of IUI is to increase the number of sperm that reach the fallopian tubes and increase the chances of fertilization.

IUI is often used as a first-line treatment for couples with unexplained infertility, mild male factor infertility, or ovulation disorders. It can also be used in conjunction with ovarian stimulation medications to increase the chances of success.

 

Procedure of IUI:

The procedure for IUI typically involves the following steps:

  • Monitoring ovulation: Before undergoing IUI, a woman may undergo monitoring to determine the best time for the procedure. This may involve blood tests and ultrasounds to track the growth of follicles in the ovaries and determine when ovulation will occur.
  • Semen collection and preparation: The male partner will be asked to provide a semen sample on the day of the IUI procedure. The sample will be washed and concentrated to remove any impurities and increase the number of healthy sperm.
  • IUI procedure: The IUI procedure itself is relatively simple and painless. The washed sperm will be inserted into the uterus using a catheter, which is inserted through the cervix. The procedure typically takes only a few minutes to complete.
  • Rest and recovery: After the IUI procedure, the woman may be advised to rest for a short period of time before resuming normal activities. She may experience some cramping or spotting, which is normal.
  • Follow-up: Approximately two weeks after the IUI procedure, the woman will undergo a pregnancy test to determine if the procedure was successful.

 

Success rate of IUI in India:

The success rate of IUI in India can vary depending on several factors, including the age of the woman, the cause of infertility, and the number of IUI cycles performed.

According to a study published in the Indian Journal of Community Medicine, the overall success rate of IUI in India ranges from 10% to 20% per cycle. However, success rates can be as high as 40% to 50% for couples with unexplained infertility who undergo three or more cycles of IUI.

Other factors that can impact the success of IUI include:

  • Age: The success rate of IUI decreases with age, particularly after the age of 35.
  • Cause of infertility: The cause of infertility can impact the success of IUI. Couples with male factor infertility or ovulation disorders may have a higher success rate than those with tubal factor infertility.
  • Number of cycles: The success rate of IUI increases with the number of cycles performed. Couples who undergo multiple cycles of IUI may have a higher chance of success than those who only undergo one or two cycles.
  • Use of ovarian stimulation medications: The use of ovarian stimulation medications can increase the success rate of IUI by increasing the number of eggs available for fertilization.

It is important to discuss the potential success and risks of IUI with a qualified healthcare provider before starting treatment. Additionally, couples may want to consider exploring other fertility treatment options, such as in vitro fertilization (IVF), if IUI is not successful.

 

Benefits of IUI:

Intrauterine insemination (IUI) offers several benefits as a fertility treatment, including:

  • Non-invasive: IUI is a non-invasive procedure that does not require surgery or anesthesia.
  • Cost-effective: IUI is generally less expensive than other fertility treatments, such as in vitro fertilization (IVF).
  • Increased chance of conception: IUI can increase the chances of conception by placing washed and concentrated sperm directly into the uterus at the time of ovulation.
  • Minimal discomfort: The IUI procedure is relatively simple and painless, and most women experience only mild discomfort.
  • Controlled timing: IUI allows for the timing of conception to be controlled, which can be helpful for couples with irregular menstrual cycles or other fertility issues.

Compatibility with donor sperm: IUI can be used with donor sperm, allowing couples with male factor infertility or same-sex couples to conceive.

 

Risks of IUI:

While IUI is generally considered a safe and effective fertility treatment, it does carry some risks, including:

  • Multiple pregnancy: One of the biggest risks of IUI is the possibility of a multiple pregnancy. Because IUI increases the chances of fertilization, there is a higher risk of conceiving twins, triplets, or more.
  • Ovarian hyperstimulation syndrome (OHSS): In some cases, the use of ovarian stimulation medications during IUI can cause OHSS, a potentially serious condition that can cause abdominal pain, nausea, and other symptoms.
  • Infection: There is a small risk of infection associated with any medical procedure, including IUI.
  • Ectopic pregnancy: While rare, there is a risk of ectopic pregnancy with IUI. This occurs when the fertilized egg implants outside of the uterus, typically in the fallopian tube.

 

Cost of IUI in India:

The cost of IUI in India can vary depending on several factors, including the clinic or hospital where the procedure is performed, the number of cycles required, and any additional treatments or medications needed.

On average, the cost of a single IUI cycle in India ranges from Rs. 10,000 to Rs. 20,000. However, additional costs may be incurred for medications, monitoring, and other services.

Compared to other fertility treatments, IUI is generally less expensive than in vitro fertilization (IVF), which can cost anywhere from Rs. 1,00,000 to Rs. 2,00,000 per cycle.

It is important to note that insurance coverage for fertility treatments can vary, and many insurance plans do not cover the cost of IUI or other fertility treatments. Patients should check with their insurance provider to determine what, if any, coverage is available.

In conclusion, IUI can be a cost-effective and minimally invasive option for couples struggling with infertility. However, like any medical procedure, it is important to discuss the potential risks and benefits with a qualified healthcare provider before starting treatment. Patients should also consider the costs of IUI and explore any available insurance coverage or financial assistance options.

 

3. Laparoscopy:

Laparoscopy is a surgical procedure that involves the use of a laparoscope, a thin, lighted instrument with a camera attached, to view and operate on the organs inside the abdomen. This minimally invasive technique is often used to diagnose and treat a variety of conditions, including infertility, endometriosis, and ovarian cysts.

 

Treatment Procedure of Laparoscopy:

Laparoscopy is typically performed under general anesthesia and involves making a small incision near the navel to insert the laparoscope. Additional small incisions may be made in the abdomen to allow for the insertion of other surgical instruments.

Once the laparoscope is inserted, the surgeon can view the abdominal organs on a monitor and use the surgical instruments to perform the necessary procedures. These may include removing cysts or adhesions, repairing or removing the fallopian tubes, or removing endometrial tissue.

After the procedure is complete, the instruments are removed and the incisions are closed with stitches or surgical tape. Patients may experience some discomfort and pain after the procedure, but this can usually be managed with pain medication and rest.

 

Success rate of Laparoscopy in India:

The success rate of laparoscopy in India varies depending on the specific condition being treated and the individual patient’s circumstances. However, laparoscopy has been shown to be an effective treatment option for a variety of gynecological and fertility-related conditions.

For example, laparoscopic surgery for endometriosis has been shown to result in a significant reduction in pain and improvement in fertility outcomes. Similarly, laparoscopic surgery for ovarian cysts has been shown to be safe and effective, with a low risk of complications.

Overall, the success rate of laparoscopy in India is generally high, and many patients are able to achieve improved fertility outcomes and better overall health following the procedure.

It is important to note that the success of laparoscopy depends not only on the surgical technique but also on the individual patient’s overall health, age, and specific condition. Patients should discuss their individual chances of success with their healthcare provider before undergoing the procedure.

 

Benefits of Laparoscopy:

Laparoscopy offers several benefits as a surgical procedure, including:

  • Minimally invasive: Laparoscopy is a minimally invasive technique that involves smaller incisions and less tissue damage than traditional open surgery.
  • Shorter recovery time: Because laparoscopy involves smaller incisions and less tissue damage, patients typically experience less pain and have a shorter recovery time than with open surgery.
  • Improved fertility outcomes: Laparoscopy can be an effective treatment for infertility caused by conditions such as endometriosis, ovarian cysts, and fallopian tube blockages.
  • Reduced risk of complications: Because laparoscopy is a minimally invasive technique, it is associated with a lower risk of complications such as infection, bleeding, and scarring.

 

Risks of Laparoscopy:

While laparoscopy is generally considered a safe and effective surgical procedure, it does carry some risks, including:

  • Bleeding: There is a small risk of bleeding during or after laparoscopy.
  • Infection: Like any surgical procedure, there is a risk of infection with laparoscopy.
  • Damage to surrounding organs: There is a small risk of damage to surrounding organs, such as the bladder or intestines, during laparoscopy.
  • Anaesthesia complications: As with any surgery, there is a risk of complications related to general anaesthesia.

 

Cost of Laparoscopy in India:

The cost of laparoscopy in India can vary depending on several factors, including the location of the hospital or clinic, the specific condition being treated, and the individual patient’s health insurance coverage.

In general, laparoscopy is considered a relatively affordable surgical procedure in India, with costs ranging from approximately INR 20,000 to INR 80,000 or more, depending on the factors listed above.

Patients should consult with their healthcare provider or insurance provider to determine their individual costs and coverage for laparoscopy. Some insurance plans may cover all or part of the cost of laparoscopy, while others may require patients to pay out of pocket.

In addition to the direct costs of the procedure itself, patients should also consider the indirect costs associated with laparoscopy, such as travel and lodging expenses, time off work, and any additional medications or follow-up care.

Overall, laparoscopy is a safe and effective surgical procedure that offers several benefits for patients with gynaecological or fertility-related conditions. Patients should carefully weigh the potential risks and benefits of laparoscopy and discuss their options with their healthcare provider before undergoing the procedure.

 

4. Intracytoplasmic Sperm Injection (ICSI):

INTRACYTOPLASMIC SPERM INJECTION (ICSI) is a form of assisted reproductive technology (ART) that is commonly used to treat male infertility. It involves injecting a single sperm directly into an egg to achieve fertilization, bypassing any barriers to fertilization that may exist.

 

Treatment Procedure of ICSI:

ICSI treatment typically involves several steps. First, the female partner undergoes ovarian stimulation to produce multiple mature eggs. Then, the eggs are retrieved from the ovaries and prepared for fertilization.

Meanwhile, the male partner provides a semen sample, which is processed in the laboratory to separate the healthy sperm from other components. The best quality sperm are then selected for injection into the eggs.

During the ICSI procedure, a single sperm is injected directly into the center of each mature egg using a very fine needle. The eggs are then closely monitored for signs of fertilization and development.

After several days, the resulting embryos are transferred to the woman’s uterus for implantation and pregnancy.

 

Success rate of  ICSI in India:

The success rate of ICSI in India varies depending on several factors, including the age and health of the female partner, the quality of the sperm used for fertilization, and the skill and experience of the healthcare team performing the procedure.

On average, the success rate of ICSI in India is around 40-50% per cycle, although this can vary widely from individual to individual.

Factors that may increase the likelihood of success with ICSI include using high-quality sperm, performing pre-implantation genetic testing to screen for genetic abnormalities, and transferring multiple embryos to increase the chances of successful implantation.

 

Benefits of ICSI:

ICSI offers several benefits for couples struggling with male infertility. For example, it can enable couples to achieve a pregnancy when conventional methods of assisted reproductive technology have failed, such as in cases where the male partner has a low sperm count or poor sperm motility.

ICSI may also be useful in cases where the male partner has obstructive or non-obstructive azoospermia, which involves a complete absence of sperm in the semen.

 

Risks of ICSI:

Like all medical procedures, ICSI carries some risks and potential side effects. For example, there is a risk of infection or bleeding at the site of the egg retrieval or injection.

Additionally, there is a small risk of genetic abnormalities or birth defects in children conceived through ICSI, although this risk appears to be low overall.

 

Cost of ICSI in India:

The cost of ICSI in India varies depending on several factors, including the location of the clinic or hospital, the specific services included in the treatment package, and the individual patient’s health insurance coverage.

On average, the cost of a single cycle of ICSI in India can range from approximately INR 1 lakh to INR 2.5 lakhs or more. Patients should consult with their healthcare provider or insurance provider to determine their individual costs and coverage for ICSI.

In addition to the direct costs of the procedure itself, patients should also consider the indirect costs associated with ICSI, such as travel and lodging expenses, time off work, and any additional medications or follow-up care.

Overall, ICSI is a safe and effective form of assisted reproductive technology that can help couples achieve a pregnancy when other methods have failed. Patients should carefully consider the potential risks and benefits of ICSI and discuss their options with their healthcare provider before undergoing the procedure.

Also read: What are Tubectomy and Tubectomy Reversal?

FAQ:

Q: What is the treatment before IVF?

A: Before starting IVF treatment, doctors typically recommend a thorough evaluation of both partners to identify any underlying fertility issues. This may involve tests such as semen analysis for the male partner, hormone testing for the female partner, and imaging tests to assess the condition of the reproductive organs.

Q: How long do you take fertility drugs before IVF?

A: The length of time that fertility drugs are taken before IVF can vary depending on individual circumstances. Typically, a woman will take fertility drugs for around 10-12 days before undergoing egg retrieval. However, the specific protocol will be determined by the treating physician based on factors such as age, ovarian reserve, and previous response to fertility medications.

Q: What fertility tests are done before IVF?

A: Several fertility tests are typically done before starting IVF treatment. For the female partner, these may include blood tests to measure hormone levels, a transvaginal ultrasound to assess the ovaries and uterus, and a hysterosalpingogram to check the fallopian tubes. For the male partner, a semen analysis may be performed to assess sperm count and motility.

Q: What are the 3 main types of fertility treatments?

A: The three main types of fertility treatments are:

  • Medications to stimulate ovulation, such as Clomid or letrozole.
  • Intrauterine insemination (IUI), which involves placing sperm directly into the uterus.
  • Assisted reproductive technologies (ART), which includes IVF and other procedures that involve fertilization outside of the body.

Q: How do I prepare my uterus for IVF?

A: Prior to IVF treatment, doctors may recommend a procedure called a hysteroscopy to evaluate the uterine lining and identify any issues that may affect implantation. Additionally, medications such as estrogen and progesterone may be prescribed to help prepare the uterine lining for embryo transfer.

Q: When is the best time to start fertility treatment?

A: The best time to start fertility treatment can vary depending on individual circumstances. Generally, it is recommended that couples seek evaluation if they have been trying to conceive for a year or more without success. However, if there are known fertility issues, treatment may be recommended sooner.

Q: What is the best time to take fertility drugs?

A: The best time to take fertility drugs will be determined by the treating physician based on individual circumstances. Typically, medications to stimulate ovulation are taken for several days at the beginning of a woman’s menstrual cycle.

Q: When is the best time to start IVF?

A: The best time to start IVF will depend on individual circumstances and factors such as age, ovarian reserve, and previous fertility treatments. Generally, it is recommended that couples consider IVF if other fertility treatments have been unsuccessful or if there are known fertility issues that may impact the success of other treatments.

Q: What age is IVF most successful?

A: IVF success rates tend to decline with age, and the highest success rates are typically seen in women under the age of 35. However, individual factors such as ovarian reserve and previous fertility treatments can also impact the success of IVF.

Q: Do they wash sperm before IVF?

A: Yes, sperm are typically washed and prepared in a laboratory prior to IVF treatment. This process helps to concentrate healthy, motile sperm and remove any debris or other substances that may affect fertilization.

Q: How can I improve my egg quality for IVF?

A: There are several lifestyle factors that may help to improve egg quality, such as maintaining a healthy weight, avoiding smoking and excessive alcohol consumption, and managing stress levels. Additionally, fertility medications may be used to help improve egg quality in some cases.

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    Dr Mona Dahiya

    Dr Mona Dahiya

    IVF Specialist & Consultant

    Dr Mona Dahiya has performed over 5,000+ IVF cycles and is considered a global expert in IVF, ICSI, IUI and male fertility treatment. She is an eminent writer on Infertility Treatment and has over 100 Publications in both International and National Journals. Dr Mona Dahiya has immensely contributed to the field of infertility through her Research and articles.

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