Risks & Side Effects Of IVF Injections & Stimulation Drugs

by | Apr 7, 2023 | IVF

Side Effects Of IVF Injections & Stimulation Drugs

What is IVF?

Side Effects Of IVF- In Vitro Fertilization (IVF) is a medical procedure where an egg is fertilized by sperm outside the body, usually in a laboratory. The resulting embryo(s) are then transferred into the woman’s uterus in hopes of implantation and successful pregnancy. IVF has helped millions of people worldwide overcome fertility challenges and experience the joy of parenthood.


Who Needs IVF?

IVF isn’t solely for couples facing infertility; it’s also a viable option for same-sex couples and single individuals looking to start a family. Through donor eggs, sperm, or embryos, IVF provides an opportunity for people from all walks of life to experience parenthood.


What Are IVF Injections?

IVF injections, also known as fertility drugs, are prescribed to women undergoing IVF treatments to increase the chances of successful conception. These medications stimulate the ovaries to produce multiple eggs, which are then harvested, fertilized in a laboratory, and transferred to the woman’s uterus. Some common fertility drugs used in IVF treatments include Gonadotropin-releasing hormone (GnRH) agonists, GnRH antagonists, and human chorionic gonadotropin (HCG).


Why Injections are Given in IVF?

Injections are a crucial part of the IVF process, and there are several reasons why they’re used:

  1. Stimulating the ovaries: Fertility medications are administered through injections to stimulate the ovaries, encouraging themto produce multiple eggs. This increases the chances of successful fertilization and implantation.
  1. Suppressing natural hormones: In some cases, injections are used to suppress the body’s natural hormone production, allowing doctors to have greater control over the IVF process. This ensures optimal timing for egg retrieval and embryo transfer.
  2. Triggering ovulation: Once the eggs have matured, a “trigger shot” is given to stimulate the final stage of egg maturation and trigger ovulation. This precisely timed injection is crucial for successful egg retrieval.
  3. Supporting embryo implantation: After the embryo transfer, injections of progesterone or human chorionic gonadotropin (hCG) may be given to support the lining of the uterus and promote successful implantation.

Although injections may seem intimidating, they play a vital role in the IVF process. Your fertility specialist will guide you through each step, ensuring you understand the purpose of each medication and how to administer it correctly.

IVF Injections Names:

There are several types of injections used during IVF treatments. Each serves a specific purpose in the process.

Ovarian Stimulation Medications:

These medications encourage the ovaries to produce multiple eggs, increasing the chances of successful fertilization. Common medications include:

  • Follitropin alfa (Gonal-F)
  • Follitropin beta (Follistim)
  • Menotropins (Menopur)

Gonadotropin-Releasing Hormone (GnRH) Medications:

These injections regulate hormone production, ensuring optimal timing for egg retrieval and embryo transfer. They can be classified as agonists or antagonists:

  • GnRH agonists (e.g., Leuprolide acetate / Lupron): Suppress the body’s natural hormone production, allowing for greater control over the IVF process.
  • GnRH antagonists (e.g., Ganirelix acetate / Antagon, Cetrotide): Block the effects of GnRH, preventing premature ovulation.

Trigger Shots:

These injections are administered to stimulate the final stage of egg maturation and trigger ovulation. Examples include:

  • Human chorionic gonadotropin (HCG) (e.g., Ovidrel, Pregnyl)
  • Gonadotropin-releasing hormone agonist (GnRH agonist) (e.g., Lupron)

Luteal Support Medications:

After embryo transfer, luteal support medications are used to promote the growth of the uterine lining and support implantation. Common medications include:

  • Progesterone (e.g., Endometrin, Crinone, PIO)


How Many Injections Are Given in IVF?

The number of injections during an IVF cycle depends on the individual’s response to treatment and the chosen protocol. On average, a patient may receive:

  • 10-12 injections for ovarian stimulation
  • Daily injections of GnRH medications (agonists or antagonists) throughout stimulation
  • A single trigger shot injection
  • Luteal support injections as needed after embryo transfer


IVF Injections Given for How Many Days?

The duration of IVF injections varies depending on the individual and the specific treatment plan. Here’s a general overview of the timeline:

  1. Ovarian stimulation medications: These injections are typically administered for 8-12 days. The exact duration depends on how your ovaries respond to the medications and when your eggs reach maturity.
  2. GnRH medications: The use of GnRH agonists or antagonists may start before or alongside ovarian stimulation injections and continue until the day of the trigger shot. The duration typically ranges from 5-14 days.
  3. Trigger shot: This single injection is administered approximately 36 hours before the scheduled egg retrieval.
  4. Luteal support medications: Progesterone injections or suppositories are usually started within a day or two after egg retrieval and may continue for 8-10 weeks if pregnancy is achieved. In some cases, the duration may be adjusted based on your doctor’s recommendations.


IVF Injections Side Effects:

IVF injections can be a godsend for couples struggling with infertility, but they are not without their drawbacks. While the primary goal is to promote ovulation and egg development, the process can sometimes result in side effects that range from mild to severe.

Common Side Effects of IVF Injections:

Mild Side Effects of IVF Injections:

Most women experience mild side effects from fertility drugs, which are generally short-lived and manageable. Some of these include:

  • Bloating and abdominal discomfort: As the ovaries are stimulated to produce multiple eggs, they may become swollen, causing discomfort and bloating.
  • Mood swings and irritability: The hormonal changes induced by fertility drugs can lead to mood swings, irritability, and even mild depression in some cases.
  • Headaches and fatigue: These are common side effects of fertility drugs and can be managed with over-the-counter pain relievers and rest.

Serious Side Effects of IVF Injections:

While less common, serious side effects can also occur. These include:

  • Ovarian Hyperstimulation Syndrome (OHSS): This condition occurs when the ovaries respond too strongly to fertility drugs, causing severe swelling and pain. In rare cases, it can lead to more severe complications, such as blood clots, kidney failure, or ovarian torsion.
  • Multiple pregnancies: The use of fertility drugs increases the chances of multiple pregnancies, which can carry additional risks for both the mother and the babies.


Long-Term Side Effects of IVF Injections:

As for the long-term effects of IVF injections, there is no definitive answer. Some studies have suggested a potential link between fertility drugs and an increased risk of certain types of cancer, such as ovarian and breast cancer. However, other research has found no such association. It’s important to discuss these potential risks with your doctor and weigh them against the benefits of IVF treatment.

Reducing Side Effects from IVF Fertility Drugs:

Although some side effects are unavoidable, there are steps you can take to minimize the risks associated with IVF injections:

  1. Follow your doctor’s instructions closely: It’s crucial to use the prescribed dosage and follow your doctor’s instructions to minimize the risk of complications.
  2. Stay well-hydrated: Drinking plenty of water can help alleviate bloating and abdominal discomfort.
  3. Prioritize self-care: Make time for relaxation, exercise, and a balanced diet to help manage stress and support overall well-being during your fertility journey.


The Bottom Line

IVF injections can be a life-changing treatment for couples struggling with infertility, but they can also come with some side effects. It’s essential to be aware of these potential issues and work closely with your healthcare team to manage them effectively.

While the short-term side effects of IVF injections are generally mild and manageable, the long-term effects remain a topic of ongoing research. It’s important to stay informed, discuss your concerns with your doctor, and weigh the risks and benefits of fertility treatments.

Remember, each individual’s experience with IVF injections will be unique. By taking the necessary precautions and prioritizing self-care, you can increase your chances of a successful IVF journey while minimizing potential side effects.

In the end, IVF treatments can offer hope to millions of couples longing to become parents. By understanding the possible side effects of fertility drugs and working closely with your healthcare team, you can make informed decisions and embark on your path to parenthood with confidence.


The Risks and Benefits of IVF Injections:

Weighing the Risks of IVF Injections:

While IVF has helped many couples achieve their dream of parenthood, it’s important to be aware of the potential IVF risks involved. Some of the most common risks include:

  • Ovarian Hyperstimulation Syndrome (OHSS): This condition occurs when the ovaries become overly stimulated by fertility drugs, leading to pain, bloating, and, in rare cases, more severe complications.
  • Ectopic pregnancy: Although rare, IVF can increase the likelihood of an ectopic pregnancy, where the embryo implants outside the uterus.
  • Multiple pregnancies: IVF treatments increase the chances of multiple pregnancies, which can carry additional risks for both the mother and the babies.


Embracing the Benefits:

Despite these risks, IVF has several key benefits that make it a popular choice for couples struggling with infertility:

  • Increased chances of conception: IVF treatments offer a higher success rate than other fertility treatments, such as intrauterine insemination (IUI).
  • Genetic screening: Preimplantation Genetic Screening (PGS) and Preimplantation Genetic Diagnosis (PGD) can be performed during IVF to identify genetic abnormalities, reducing the risk of passing on inherited conditions.
  • Tailored treatment: IVF procedures can be customized to address specific infertility issues, making it suitable for a wide range of couples.


IVF Success Rates in India: A Promising Picture

The success rate of IVF in India has been steadily improving, with top clinics now boasting success rates comparable to those in Western countries. On average, the success rate of IVF in India ranges from 30% to 60%, depending on factors such as the patient’s age, the cause of infertility, and the quality of the clinic.

It’s essential to remember that individual success rates will vary, so it’s crucial to consult with a fertility expert to understand your unique circumstances and chances of success.


IVF Costs in India: Balancing Quality and Affordability

One of the major factors influencing couples’ decision to pursue IVF treatment is the cost. In India, the price of IVF can vary significantly depending on the location, the expertise of the fertility specialists, and the specific treatments required. On average, the cost of a single IVF cycle in India can range from ₹1,50,000 to ₹2,50,000.

While the cost of IVF in India is generally lower than in many Western countries, it’s essential not to compromise on the quality of care. Be sure to research and compare clinics, taking into account their success rates, facilities, and the expertise of fertility specialists.


Finding the Right Path for Your Fertility Journey:

As you navigate the world of IVF in India, it’s important to weigh the risks and benefits, research success rates, and carefully consider the costs. By taking the time to understand these factors, you’ll be better equipped to make informed decisions about your fertility journey.

Ultimately, IVF can be a transformative experience for couples struggling with infertility, offering hope and the possibility of parenthood. With the right support and guidance, you can embark on this journey with confidence and optimism.

When selecting the best IVF centre, don’t be afraid to ask questions and seek recommendations from friends, family, or online forums. Gathering firsthand experiences and insights can help you choose the best clinic for your needs.

It’s also important to prioritize your emotional well-being throughout your IVF journey. This process can be both physically and emotionally demanding, so it’s essential to have a strong support network of friends, family, or support groups to lean on during this time. You may also consider seeking the guidance of a therapist or counsellor who specializes in fertility issues.

Remember, every couple’s fertility journey is unique, and the path to parenthood can be filled with unexpected twists and turns. By staying informed, prioritizing self-care, and working closely with your fertility team, you can increase your chances of a successful IVF experience and make your dreams of parenthood a reality.



IVF has become an increasingly popular option for couples in India struggling with infertility. While there are potential risks and costs associated with this treatment, the benefits and success rates often outweigh these concerns. By understanding the various aspects of IVF, from risks to success rates and costs, you can make informed decisions about your fertility journey and take the first steps toward building the family you’ve always dreamed of.



Q: What are the long-term side effects of IVF injections?

A: There is limited research on the long-term side effects of IVF injections. However, some studies suggest that women who undergo multiple rounds of IVF treatment may have an increased risk of developing ovarian cancer or breast cancer.

Q: What do IVF injections do to your body?

A: IVF injections are used to stimulate a woman’s ovaries to produce multiple eggs for retrieval. These injections can cause side effects such as bloating, cramping, mood swings, and headaches.

Q: Do IVF injections cause weight gain?

A: IVF injections can cause temporary bloating and water retention, which may lead to a slight increase in weight. However, there is no evidence to suggest that IVF injections cause significant or long-term weight gain.

Q: How do IVF injections make you feel?

A: IVF injections can cause side effects such as bloating, cramping, mood swings, and headaches. Some women may also experience fatigue, nausea, or breast tenderness.

Q: What is the biggest problem with IVF?

A: The biggest problem with IVF is the relatively low success rates. Even with multiple rounds of treatment, the success rates of IVF can vary widely depending on a variety of factors, including age, fertility issues, and the quality of the embryos.

Q: What are 2 problems with IVF treatment?

A: Two problems with IVF treatment include the high cost of the procedure and the potential physical and emotional side effects that can occur during and after treatment.

Q: What age is IVF most successful?

A: IVF success rates are highest in women under the age of 35. As a woman’s age increases, the chances of success with IVF decrease.

Q: Can I get pregnant after IVF injection?

A: Yes, it is possible to get pregnant after IVF injection. IVF is a fertility treatment that is designed to increase a woman’s chances of getting pregnant.

Q: Should I rest after IVF injection?

A: It is generally recommended that women take it easy and avoid strenuous physical activity for a few days after IVF injections to reduce the risk of complications.

Q: Is IVF hard on a woman’s body?

A: IVF can be physically and emotionally taxing on a woman’s body. The injections used to stimulate the ovaries can cause side effects such as bloating, cramping, and mood swings, and the egg retrieval procedure can be uncomfortable.

Q: Does IVF cause hair loss?

A: IVF injections are not known to cause hair loss. However, the stress of undergoing IVF treatment may contribute to hair loss in some women.

Q: How successful is IVF?

A: The success rates of IVF can vary widely depending on a variety of factors, including age, fertility issues, and the quality of the embryos. On average, the success rates of IVF range from 30% to 50%.

Q: How do you sleep after IVF injection?

A: After IVF injections, it is recommended that women sleep on their side to avoid putting pressure on the ovaries.

Q: How many injections per day for IVF?

A: The number of injections required for IVF can vary depending on the individual’s treatment plan. Some women may require multiple injections per day for several weeks.

Q: Which body part is injected for IVF?

A: IVF injections are typically given in the abdomen or thigh.

Q: When should I stop IVF injections?

A: The decision to stop IVF injections should be made in consultation with a healthcare provider. In general, IVF injections are stopped after the egg retrieval procedure is complete.

Q: Are IVF injections safe?

A: IVF injections are generally considered safe, but like any medical procedure, they do carry some risks. Common side effects include bloating, cramping, and mood swings. More serious complications can occur, such as infection, bleeding, or ovarian hyperstimulation syndrome (OHSS). However, the risk of these complications is relatively low, and most women tolerate IVF injections well.

Q: Are you high risk after IVF?

A: After IVF, women are not considered to be at higher risk for complications than they were before the procedure. However, there is a slightly increased risk of complications during pregnancy, such as ectopic pregnancy or multiple gestations (twins, triplets, etc.). Women who undergo IVF may also experience higher levels of stress and anxiety, which can affect their overall health and well-being. It is important for women who undergo IVF to receive ongoing medical care and support to manage any potential risks or complications.

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    Dr Mona Dahiya

    Dr Mona Dahiya

    IVF Specialist & Consultant

    Dr Mona Dahiya has performed over 10,000+ IVF cycles and is considered a global expert in IVF, ICSI, IUI and male fertility treatment. She is an eminent writer on Infertility Treatment and has over 100 Publications in both International and National Journals. Dr Mona Dahiya has immensely contributed to the field of infertility through her Research and articles.

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