Embryo Freezing (Cryopreservation): Advantages & Succes Rate

by | Jul 25, 2023 | IVF

What is Embryo Freezing?

Embryo freezing, or cryopreservation allows individuals and couples to preserve their embryos for future use. This process involves carefully freezing embryos at extremely low temperatures, effectively halting their development until they are ready to be used for in vitro fertilization (IVF) or other assisted reproductive treatments. By storing embryos in this suspended state, individuals can overcome obstacles like age-related fertility decline, medical treatments that may harm fertility, or personal circumstances that make conceiving at the present moment difficult or undesirable.

 

Why Should You Freeze Embryo?

  1. Overcoming Biological Clock Constraints: Life often leads us on different paths, and sometimes, the right time for starting a family might not align with our desires. Embryo freezing empowers women to extend their fertile years, providing them with the opportunity to focus on their careers, personal growth, or relationships without compromising their chances of becoming parents in the future.
  1. Mitigating Fertility Challenges: Medical conditions, such as cancer, may necessitate treatments like chemotherapy or radiation, which can harm fertility. For those diagnosed with cancer, embryo freezing offers a ray of hope, allowing them to preserve their fertility before undergoing treatments that could potentially affect their ability to conceive naturally.
  1. Empowering LGBTQ+ Couples: Embryo freezing has revolutionized family planning for LGBTQ+ couples. Same-sex male couples and transgender individuals can now create embryos using donor eggs and sperm, giving them the opportunity to experience parenthood biologically related to the child.
  1. Ensuring Genetic Continuity: For couples facing genetic disorders or hereditary conditions, embryo freezing can be a lifesaver. Through pre-implantation genetic testing, viable embryos without the genetic condition can be selected for transfer during IVF, ensuring the potential child is healthy.
  1. Preserving Relationships: Embryo freezing can be an emotional journey for couples struggling with infertility. It offers a tangible symbol of hope and togetherness, fostering a sense of unity and purpose in their quest to create a family.

 

Egg Freezing vs. Embryo Freezing:

Egg freezing and embryo freezing are distinct procedures with different purposes, though both offer options for preserving fertility.

  • Egg Freezing: Egg freezing involves harvesting and freezing a woman’s eggs for later use. It provides women with the freedom to take charge of their reproductive future without the immediate need for a partner or sperm donor. Egg freezing is an excellent option for single women or those in a situation where using a partner’s sperm is not feasible or desirable.
  • Embryo Freezing: Embryo freezing, on the other hand, requires fertilization of harvested eggs with sperm to create embryos before freezing. This procedure is best suited for couples who are ready to commit to parenthood or individuals who have a partner or sperm donor in mind.

 

What is the Process of Embryo Freezing?

Embryo freezing is a sophisticated medical procedure that involves preserving embryos at sub-zero temperatures through the process of cryopreservation. Let’s break down the steps of this miraculous process:

  1. Fertility Medication and Egg Retrieval: The first step in embryo freezing begins with hormonal stimulation to encourage the ovaries to produce multiple eggs. Fertility medications are administered, and the growth of follicles containing the eggs is monitored through ultrasound and hormone level checks. Once the eggs reach the desired size, a trigger shot is given to facilitate their final maturation.
  2. Egg Retrieval: Around 36 hours after the trigger shot, the eggs are retrieved from the ovaries using a minimally invasive procedure known as transvaginal ultrasound aspiration. This process ensures the eggs are safely collected for further development.
  3. Fertilization: The retrieved eggs are then combined with sperm in a laboratory setting through either conventional insemination or intracytoplasmic sperm injection (ICSI), where a single sperm is directly injected into each egg. This step aims to achieve fertilization and the creation of embryos.
  4. Embryo Culture: The fertilized eggs, now embryos, are cultured in a controlled environment in the laboratory. Highly skilled embryologists closely monitor their development, allowing them to reach the optimal stage for freezing.
  5. Cryopreservation: Once the embryos have reached the appropriate stage of development, they are carefully frozen using a specialized freezing technique called vitrification. This rapid freezing process prevents the formation of ice crystals, ensuring the embryos remain viable during the thawing process.
  6. Storage: After vitrification, the frozen embryos are stored in cryopreservation tanks, where they can remain in suspended animation until the individual or couple is ready to use them for future IVF cycles.

 

What are the Advantages of Embryo Cryopreservation?

Embryo freezing offers an array of advantages that have transformed the landscape of family planning and fertility preservation:

  1. Extended Fertility Window: One of the most significant benefits of embryo freezing is the ability to extend the fertility window. Women can preserve their embryos when they are in their prime reproductive years, giving them the flexibility to start a family at a time that aligns with their life goals and circumstances.
  2. Enhanced IVF Success Rates: Embryo freezing contributes to improved IVF success rates, as it allows for the selection of the healthiest embryos for transfer. Pre-implantation genetic testing can be performed on the embryos, ensuring only genetically normal embryos are chosen for transfer.
  3. Medical and Personal Reasons: For individuals facing medical conditions like cancer, embryo cryopreservation offers a glimmer of hope. Patients can preserve their fertility before undergoing treatments that may harm their reproductive capabilities.
  4. Empowerment for LGBTQ+ Couples: Embryo freezing has been a game-changer for LGBTQ+ couples, enabling them to create embryos using donor eggs and sperm, providing them with a biological connection to their future child.
  5. Peace of Mind: For couples experiencing infertility, embryo freezing offers peace of mind and a renewed sense of hope. It provides a tangible symbol of their journey toward parenthood and ensures that the possibility of starting a family is never lost.

 

What are the Risks of Embryo Freezing?

As with any medical procedure, embryo freezing comes with certain risks. It’s essential to be aware of these potential risks:

  1. Embryo Viability: Not all embryos survive the freezing and thawing process. Despite advancements in technology, some embryos may not survive cryopreservation, which can be emotionally challenging for those hoping to conceive.
  2. Multiple Embryo Transfers: In some cases, multiple embryos are frozen, and it might be tempting to transfer multiple embryos to increase the chances of pregnancy. However, this can lead to a higher risk of multiple pregnancies, which may have associated complications.
  3. Ethical Considerations: Embryo freezing raises ethical questions regarding the fate of embryos that remain unused. Decisions about the disposal, donation, or continued storage of embryos can be emotionally taxing for individuals and couples.

 

IVF Success Rate with Frozen Embryo Transfer in India

India has witnessed remarkable progress in the field of IVF and embryo freezing, leading to increased success rates with frozen embryo transfers (FET). The success of FET depends on various factors, including the age of the woman, the quality of the frozen embryos, and the expertise of the fertility clinic.

 

How Long Can an Embryo Be Frozen?

Embryo freezing is a safe and effective method of preserving fertility, but how long can embryos remain frozen?

Theoretically, embryos can be stored indefinitely, as they are maintained at ultra-low temperatures that prevent cellular activity. However, the maximum recommended storage time varies by country and guidelines. In general, most fertility clinics recommend storage periods of up to 10 years, after which individuals or couples may decide to continue storage, use the embryos for fertility treatment, donate them for research, or choose to dispose of them according to their wishes and local regulations.

 

Conclusion:

Embryo freezing represents a monumental stride in reproductive medicine, offering hope, empowerment, and the chance to build families despite life’s uncertainties. The ability to preserve embryos for future use has opened doors to countless possibilities, allowing individuals and couples to fulfill their dreams of parenthood on their terms.

 

F.A.Q

Q: How is embryo freezing done?

A: Embryo freezing involves carefully preserving embryos at very low temperatures through a process known as cryopreservation, which safeguards their viability for future use.

Q: What is the best age to freeze embryos?

A: The optimal age to freeze embryos is generally in the woman’s late 20s to early 30s, as the quality of eggs and embryos tends to be higher during this period.

Q: Is embryo freezing painful?

A: No, the actual freezing process is not painful as it occurs when the embryos are in a dormant state. However, some women may experience mild discomfort during the egg retrieval process prior to freezing.

Q: What is the cost of freezing embryos in India?

A: The cost of freezing embryos in India can vary based on the clinic and the specific procedures involved, but it generally ranges from a few thousand to several tens of thousands of rupees.

Q: Are freezing embryos safe?

A: Yes, embryo freezing is considered safe and has been widely used in assisted reproductive technologies for decades with successful outcomes.

Q: Is a frozen embryo a life?

A: Philosophical and ethical debates surround the definition of life in the context of frozen embryos. Biologically, they are at a developmental stage, but they have the potential to become a living being if implanted successfully.

Q: Are frozen embryos more successful?

A: In many cases, frozen embryos have shown comparable success rates to fresh embryos in terms of pregnancy and birth rates, and they can offer advantages like flexibility in timing and reducing the risk of certain complications.

Q: Are frozen IVF babies born early?

A: There is no evidence to suggest that babies born from frozen embryos through in vitro fertilization (IVF) are more likely to be born prematurely. The timing of birth is typically based on medical considerations and not influenced by the method of embryo preservation.

Q: Are freezing embryos expensive?

A: Yes, freezing embryos can be a costly process, involving various medical procedures and ongoing storage fees. However, the exact expenses can vary depending on the location and the individual’s circumstances.

Q: What is the disadvantage of frozen embryos?

A: One potential disadvantage of frozen embryos is that not all embryos survive the freezing and thawing process, leading to a possible reduction in the number of viable embryos available for future use.

Q: What are the side effects of embryo freezing?

A: The process of embryo freezing itself does not typically cause any side effects. However, some women may experience mild discomfort or bloating following the hormone injections used to stimulate egg production before retrieval.

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    Dr Mona Dahiya

    Dr Mona Dahiya

    IVF Specialist & Consultant

    Dr Mona Dahiya has performed over 5,000+ IVF cycles and is considered a global expert in IVF, ICSI, IUI and male fertility treatment. She is an eminent writer on Infertility Treatment and has over 100 Publications in both International and National Journals. Dr Mona Dahiya has immensely contributed to the field of infertility through her Research and articles.

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