What Causes Recurrent Miscarriage?

  • Embryonic Chromosomal Abnormalities: The most common reason for early pregnancy loss includes random genetic mistakes in fertilization as well as egg quality with age.
  • Uterine Factors: Congenital anomalies (such as a uterine septum) or acquired conditions like intrauterine adhesions (Asherman syndrome), large polyps, or submucosal fibroids.
  • Immunological Conditions: Antiphospholipid syndrome (APS), an autoimmune condition where specific antibodies increase the risk of blood clots in the placenta.
  • Endocrine & Metabolic Disorders: Poorly managed diabetes, untreated hypothyroidism, or elevated prolactin levels.
  • Parental Genetic Translocations: Balanced chromosomal rearrangements in either partner that do not affect the parent’s health but may lead to unbalanced chromosomes in an embryo.
  • Lifestyle & Environmental Factors: High-dose smoking, excessive alcohol intake, and significant maternal or paternal obesity.

In approximately 40% to 50% of cases, standard evaluations reveal no single identifiable cause (unexplained RPL). Reassuringly, evidence shows that supportive care yields favorable live-birth outcomes even when tests are normal.

Recurrent Pregnancy Loss (RPL) Evaluation

Testing is never one-size-fits-all; our specialists tailor investigations to your specific medical history:

  • 3D Pelvic Ultrasound or Hysteroscopy: To evaluate the uterine cavity structure.
  • Antiphospholipid Antibody Panel: Blood tests for lupus anticoagulant, anticardiolipin, and anti-β2 glycoprotein antibodies.
  • Hormonal Screening: Fasting glucose, HbA1c, thyroid panel (TSH, free T4), and prolactin.
  • Parental Karyotyping: Blood chromosome analysis for both partners in selected cases.
  • Sperm Assessment: Advanced semen analysis, including DNA fragmentation testing where clinically indicated.

Recurrent Miscarriage Treatment Options

Identified Cause Clinical Evaluation & Treatment Approach
Uterine Septum / Adhesions Minimally invasive hysteroscopic corrective surgery
Antiphospholipid Syndrome (APS) Low-dose aspirin and prophylactic low-molecular-weight heparin (LMWH)
Thyroid / Endocrine Disorder Targeted medical management (e.g., levothyroxine) to optimize hormonal levels
Luteal Phase / Bleeding Risks Micronized vaginal progesterone support in early pregnancy where clinically indicated
Genetic Translocations / Advanced Age In Vitro Fertilization (IVF) with PGT-A (preimplantation genetic testing)

Note: While IVF and PGT-A can screen embryos for major numerical chromosome abnormalities before transfer, they cannot prevent all types of pregnancy loss.

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Recurrent Pregnancy Loss Treatment Delhi

Seeking specialized recurrent pregnancy loss treatment in Delhi allows couples access to advanced reproductive diagnostics, experienced embryology laboratories, and continuous pregnancy monitoring.

At Little Angel IVF, Dr Mona Dahiya works directly with couples through structured consultations, targeted RPL testing IVF protocols, and close clinical monitoring during the critical first trimester.

Frequently Asked Questions

1. What is recurrent miscarriage?

Recurrent miscarriage is the loss of two or more consecutive clinical pregnancies before 20–24 weeks of gestation, warranting medical evaluation.

2. What are the common causes of repeated miscarriage?

Primary causes include random chromosomal abnormalities in the embryo, uterine structural defects, blood-clotting disorders like APS, untreated thyroid or metabolic imbalances, and parental genetic variations.

3. What tests are done for recurrent pregnancy loss?

Testing typically includes pelvic imaging (such as 3D ultrasound), screening for antiphospholipid syndrome, hormonal and metabolic blood tests, and genetic karyotyping when indicated.

4. Can recurrent miscarriage be treated?

Yes. When a specific cause—such as a uterine septum, APS, or thyroid condition—is identified, targeted medical or surgical treatments significantly improve pregnancy continuation rates.

5. Is IVF recommended after recurrent miscarriages?

IVF is not required for every patient. However, IVF paired with preimplantation genetic testing (PGT-A) may be recommended if parental genetic translocations are identified or for couples with repeated chromosomal losses.

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